Active Recombinant Human IL19 protein
Cat.No. : | IL19-245H |
Product Overview : | Recombinant Human IL19(Leu25-Ala177) was expressed in NS0. |
- Specification
- Gene Information
- Related Products
Description : | Interleukin 19 (IL-19) is a member of the IL-10 family of class II alpha -helical cytokines that contains two groups, a viral homolog and cellular homolog group. Within the cellular homolog group, there are two additional groupings, one which uses IL-10 R beta as a signal transducing receptor (IL-10, IL-22, and IL-26), and one which uses IL-20 R beta as a signal transducing receptor (IL-19, IL-20, and IL-24). The 153 amino acid (aa) mature human IL-19 is secreted as a glycosylated 35-45 kDa monomer. It shares approximately 70% aa sequence identity with mouse and rat IL-19. Human IL-19 may utilize an alternate start site that adds 38 aa to the N-terminus. Although mouse IL-19 is active on human cells, human IL-19 is not active on mouse cells. IL-19 is expressed on activated keratinocytes, monocytes, and B cells. It binds a receptor complex consisting of IL-20 R alpha and IL-20 R beta. This receptor complex is also shared by IL-20 and IL-24. It has been reported that IL-19 both will and will not induce IL-6 and TNF-alpha production by monocytes. It does, however, drive T helper cell differentiation towards a Th2 response, inducing both IL-10 and production of itself. |
Source : | Mammalian cells |
Species : | Human |
Predicted N Terminal : | Leu25 |
Form : | Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein. |
Bio-activity : | Measured in a cell proliferation assay using BaF3 mouse pro‑B cells transfected with human IL-20 R alpha and human IL-20 R beta. The ED50 for this effect is typically 0.1-0.6 ng/mL. |
Molecular Mass : | Predicted Molecular Mass: 18 kDa SDS-PAGE: 20-30 kDa, reducing conditions |
Endotoxin : | <0.1 EU per 1 μg of the protein by the LAL method. |
Purity : | >95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining. |
Storage : | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 centigrade as supplied. 1 month, 2 to 8 centigrade under sterile conditions after reconstitution. 3 months, -20 to -70 centigrade under sterile conditions after reconstitution. |
Reconstitution : | Reconstitute at 500 μg/mL in PBS. |
Gene Name : | IL19 interleukin 19 [ Homo sapiens ] |
Official Symbol : | IL19 |
Synonyms : | IL19; interleukin 19; interleukin-19; IL 10C; IL 19; MDA1; melanoma differentiation associated protein like protein; NG.1; ZMDA1; melanoma differentiation associated protein-like protein; melanoma differentiation-associated protein-like protein; IL-10C; |
Gene ID : | 29949 |
mRNA Refseq : | NM_013371 |
Protein Refseq : | NP_037503 |
MIM : | 605687 |
UniProt ID : | Q9UHD0 |
Products Types
◆ Recombinant Protein | ||
IL19-147M | Recombinant Mouse IL19 Protein | +Inquiry |
IL19-146H | Recombinant Human IL19 Protein | +Inquiry |
IL19-4438H | Recombinant Human IL19 Protein, His (Fc)-Avi-tagged | +Inquiry |
IL19-156H | Recombinant Active Human IL19 Protein, His-tagged(C-ter) | +Inquiry |
Il19-1015M | Recombinant Mouse Il19 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
IL19-5242HCL | Recombinant Human IL19 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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