Address: 45-1 Ramsey Road, Shirley, NY 11967, USA    USA: 1-631-559-9269  1-631-448-7888   Fax: 1-631-938-8127  Europe: 44-207-097-1828   Email: info@creative-biomart.com
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Recombinant Human IL9 protein

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Cat.No.:
IL9-222H
Product Overview:
Recombinant Human IL9(Gln19-Ile144) was expressed in Insect cells.
Description:
Interleukin-9 (IL-9), also known as P40 and MEA (mast cell growth-enhancing activity), is a 30-40 kDa glycosylated member of a cytokine family that includes Interleukins-2, -4, -7, -15, and -21. These proteins utilize heteromeric receptors containing the Common gamma chain ( gamma c) in addition to ligand-specific subunits. IL-9 interacts selectively with IL-9 R which then associates with gamma c to form the functional receptor complex. IL-9 contributes to allergic inflammation, autoimmunity-induced inflammation, parasite clearance from the GI tract, and Treg-mediated immune suppression. It enhances the expansion and recruitment of mast cells and eosinophils as well as the production of IgE and Th2 cytokines. It is required for anaphylactic responses to ingested allergens but not to systemic allergens. IL-9 plays multiple roles in the development and function of subsets within the CD4+ T cell lineage. It is expressed by activated Th9, Th17, Treg, and Th2 cells. IL-9 acts as an autocrine growth and activation factor for Th17, Treg, and mast cells. It also can inhibit immune responses by enhancing the suppressive properties of Treg and by recruiting immune-suppressive mast cells to sites of inflammation. Mature human IL-9 shares 57% amino acid sequence identity with mouse and rat IL-9.
Source:
Insect cells
Species:
Human
Predicted N Terminal:
No results obtained. Gln19 inferred from enzymatic pyroglutamate treatment revealing Gly20
Form:
Lyophilized from a 0.2 μm filtered solution in PBS.
Bio-activity:
Measured in a cell proliferation assay using MO7e human megakaryocytic leukemic cells. Avanzi, G. et al. (1988) Br. J. Haematol. 69:359. The ED50 for this effect is 0.03-0.3 ng/mL.
Molecular Mass:
Predicted Molecular Mass: 14 kDa
SDS-PAGE: 12-24 kDa, reducing conditions
Endotoxin:
<0.1 EU per 1 μg of the protein by the LAL method.
Purity:
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Storage:
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 centigrade as supplied.
1 month, 2 to 8 centigrade under sterile conditions after reconstitution.
3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
Reconstitution:
Reconstitute at 100 μg/mL in PBS.


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Optional requirements on this protein +Expand
C-fusion   N-fusion  Non-tagged
His   GST  Fc  Others
<1.0 eu/μg   <0.1 eu/μg  <0.01 eu/μg  Not required
Monomer Isolation   Dimer Isolation   Not required
>80% by SDS-PAGE   >90% by SDS-PAGE  >95% by SDS-PAGE  Others
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45-1 Ramsey Road, Shirley, NY 11967, USA
USA: 1-631-559-9269  1-631-448-7888
Europe: 44-207-097-1828
FAX: 1-631-938-8127
EMAIL: info@creative-biomart.com

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