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Active Recombinant Human KDM1A protein, GST-tagged

Cat.No. : KDM1A-15H
Product Overview : Recombinant Human KDM1A(158–end) fused with GST tag at N-terminal was expressed in E. coli.
  • Specification
  • Gene Information
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Description : This gene encodes a nuclear protein containing a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase. Alternative splicing results in multiple transcript variants.
Source : E. coli
Species : Human
Tag : GST
Form : 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 3 mM DTT, 20% glycerol, and 16 mM glutathione
Bio-activity : ≥0.50 pmole/min/μg
Molecular Mass : 104 kDa
Purity : ≥67%
Applications : Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Storage : At least 6 months at –80 centigrade. Avoid freeze/thaw cycles. Storing diluted enzyme is not recommended, if necessary, use carrier protein (BSA 0.1 – 0.5%).
Concentration : 3.0 mg/ml
Gene Name : KDM1A lysine (K)-specific demethylase 1A [ Homo sapiens ]
Official Symbol : KDM1A
Synonyms : KDM1A; lysine (K)-specific demethylase 1A; amine oxidase (flavin containing) domain 2 , AOF2, KDM1, lysine (K) specific demethylase 1; lysine-specific histone demethylase 1A; BHC110; KIAA0601; LSD1; lysine (K)-specific demethylase 1; BRAF35-HDAC complex protein BHC110; lysine-specific histone demethylase 1; amine oxidase (flavin containing) domain 2; FAD-binding protein BRAF35-HDAC complex, 110 kDa subunit; flavin-containing amine oxidase domain-containing protein 2; AOF2; KDM1;
Gene ID : 23028
mRNA Refseq : NM_015013
Protein Refseq : NP_055828
MIM : 609132
UniProt ID : O60341
Chromosome Location : 1p36.12
Pathway : Coregulation of Androgen receptor activity, organism-specific biosystem; Factors involved in megakaryocyte development and platelet production, organism-specific biosystem; Hemostasis, organism-specific biosystem; Notch signaling pathway, organism-specific biosystem; Notch-mediated HES/HEY network, organism-specific biosystem;
Function : MRF binding; androgen receptor binding; chromatin binding; demethylase activity; enzyme binding; flavin adenine dinucleotide binding; histone demethylase activity; histone demethylase activity (H3-K4 specific); histone demethylase activity (H3-K9 specific); histone demethylase activity (H3-dimethyl-K4 specific); ligand-dependent nuclear receptor transcription coactivator activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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