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Recombinant Human KIT (D816V) protein, GST-tagged

Cat.No. : KIT-30H
Product Overview : Recombinant Human KIT (D816V) mutant fused with GST tag was expressed in E. coli.
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  • Gene Information
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Source : E. coli
Species : Human
Tag : GST
Form : Phosphate-Buffered Saline (PBS), pH 7.4. No preservatives added
Molecular Mass : 135 kDa
AA Sequence : MRGARGAWDFLCVLLLLLRVQTGSS QPSVSPGEPSPPSIHPGKSDLIVRV GDEIRLLCTDPGFVKWTFEILDETN ENKQNEWITEKAEATNTGKYTCTNK HGLSNSIYVFVRDPAKLFLVDRSLY GKEDNDTLVRCPLTDPEVTNYSLKG CQGKPLPKDLRFIPDPKAGIMIKSV KRAYHRLCLHCSVDQEGKSVLSEKF ILKVRPAFKAVPVVSVSKASYLLRE GEEFTVTCTIKDVSSSVYSTWKREN SQTKL
Purity : >90 % as determined by SDS-PAGE analysis
Applications : SDS-PAGE; Western Blot (Recombinant protein); Antibody Production; Protein Array
Storage : Store at - 80 °C. Avoid repeated freeze/thaw cycles
Gene Name : KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog [ Homo sapiens ]
Official Symbol : KIT
Synonyms : KIT; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; PBT, piebald trait; mast/stem cell growth factor receptor Kit; C Kit; CD117; SCFR; p145 c-kit; proto-oncogene c-Kit; piebald trait protein; soluble KIT variant 1; tyrosine-protein kinase Kit; proto-oncogene tyrosine-protein kinase Kit; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein; PBT; C-Kit;
Gene ID : 3815
mRNA Refseq : NM_000222
Protein Refseq : NP_000213
MIM : 164920
UniProt ID : P10721
Chromosome Location : 4q11-q12
Pathway : Acute myeloid leukemia, organism-specific biosystem; Acute myeloid leukemia, conserved biosystem; C-MYB transcription factor network, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Endocytosis, organism-specific biosystem; Endocytosis, conserved biosystem;
Function : ATP binding; cytokine binding; metal ion binding; nucleotide binding; protease binding; protein binding; protein homodimerization activity; protein tyrosine kinase activity; receptor activity; receptor signaling protein tyrosine kinase activity; stem cell

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does KIT gene expression vary in different tissues, and what factors contribute to tissue-specific regulation? 02/13/2022

KIT expression varies across tissues due to tissue-specific transcription factors, epigenetic modifications, and microenvironmental cues influencing its regulation.

How is the expression of the KIT gene regulated at the transcriptional level? 01/14/2022

Transcription factors like PU.1 and GATA-2, along with epigenetic modifications, regulate KIT gene expression.

Contribution of KIT gene to germ cell maintenance in the testes and ovaries? 01/17/2020

KIT is crucial for germ cell survival and proliferation; mutations may lead to infertility.

What is the role of KIT gene in stem cell biology and regenerative medicine? 12/25/2019

KIT maintains and influences stem cell behavior, holding potential in regenerative medicine.

Role of KIT gene in hematopoiesis and implications in hematological disorders? 11/03/2018

KIT is vital in hematopoietic stem cell development; mutations link to leukemia and mastocytosis.

Customer Reviews (3)

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Reviews
11/28/2020

    The quality control measures are evident in the performance of this product.

    04/02/2019

      Exceptional service!

      07/19/2018

        Rapid delivery! Ordered and received the product within a short timeframe, allowing us to proceed with our experiments without delays.

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