Recombinant Human KIT protein, Fc-tagged
Cat.No. : | KIT-443H |
Product Overview : | Recombinant Human KIT (Gln26-Thr516) protein was fused to human IgG1 Fc tag at C-terminus and expressed in human 293 cells (HEK293). |
- Specification
- Gene Information
- Related Products
Description : | Mast/stem cell growth factor receptor Kit (c-Kit), a member of the protein kinase superfamily, Tyr protein kinase family and CSF-1/PDGF receptor subfamily, is also known as piebald trait protein (PBT), p145 c-kit, tyrosine-protein kinase Kit and CD117,which contains five Ig-like C2-type (immunoglobulin-like) domains and one protein kinase domain. CD117 acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, CD117 can activate several signaling pathways. Furthermore, Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. |
Source : | HEK293 |
Species : | Human |
Tag : | human IgG1 Fc |
Predicted N Terminal : | Gln26 |
Form : | Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5, 10% trehalose. |
Molecular Mass : | The protein has a calculated MW of 81.9 kDa. The protein migrates as 100-125 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Protein length : | Gln26-Thr516 |
Endotoxin : | Less than 1.0 EU per μg by the LAL method. |
Purity : | >95% as determined by SDS-PAGE. |
Storage : | For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: -20 to -70 centigrade for 12 months in lyophilized state; -70 centigrade for 3 months under sterile conditions after reconstitution. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents. |
Gene Name : | KIT |
Official Symbol : | KIT |
Synonyms : | KIT; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; PBT, piebald trait; mast/stem cell growth factor receptor Kit; C Kit; CD117; SCFR; p145 c-kit; proto-oncogene c-Kit; piebald trait protein; soluble KIT variant 1; tyrosine-protein kinase Kit; proto-oncogene tyrosine-protein kinase Kit; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein; PBT; C-Kit |
Gene ID : | 3815 |
mRNA Refseq : | NM_000222 |
Protein Refseq : | NP_000213 |
MIM : | 164920 |
UniProt ID : | P10721 |
Products Types
◆ Recombinant Protein | ||
KIT-3219H | Recombinant Human KIT Protein, His (Fc)-Avi-tagged | +Inquiry |
KIT-121H | Recombinant Human KIT Protein, His-tagged | +Inquiry |
Kit-4037M | Active Recombinant Mouse Kit protein(Met1-Thr523), hFc-tagged | +Inquiry |
KIT-223H | Recombinant Human KIT Protein (ECD), Fc-His-tagged(C-ter) | +Inquiry |
KIT-2230R | Recombinant Rhesus Macaque KIT Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
KIT-2114MCL | Recombinant Mouse KIT cell lysate | +Inquiry |
KIT-463HCL | Recombinant Human KIT cell lysate | +Inquiry |
KIT-1324RCL | Recombinant Rat KIT cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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