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Recombinant Human KLKB1 protein, His-tagged

Cat.No. : KLKB1-485H
Product Overview : Recombinant Human KLKB1(Gly20-Ala638) fused with His tag at C-terminal was expressed in HEK293.
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Description : KLKB1 is a 638 amino acids protein that belongs to the peptidase S1 family and plasma kallikrein subfamily. It contains a peptidase S1 domain and four apple domains. The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin. It participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation.Plasma prekallikrein deficiency causes a prolonged activated partial thromboplastin time in patients.
Source : HEK293
Species : Human
Tag : His
Form : Supplied as a 0.2 μm filtered solution of 20mM TrisHCl, 150mM NaCl, 10% Glycerol, pH8.0
Protein length : Gly20-Ala638
AA Sequence : GCLTQLYENAFFRGGDVASMYTPNA QYCQMRCTFHPRCLLFSFLPASSIN DMEKRFGCFLKDSVT GTLPKVHRTGAVSGHSLKQCGHQIS ACHRDIYKGVDMRGVNFNVSKVSSV EECQKRCTNNIRCQF FSYATQTFHKAEYRNNCLLKYSPGG TPTAIKVLSNVESGFSLKPCALSEI GCHMNIFQHLAFSDV DVARVLTPDAFVCRTICTYHPNCLF FTFYTNVWKIESQRNVCLLKTSESG TPSSSTPQENTISGY SLLTCKRTLPEPCHSKIYPGVDFGG EELNVTFVKGVNVCQETCTKMIRCQ FFTYSLLPEDCKEEK CKCFLRLSMDGSPTRIAYGTQGSSG YSLRLCNTGDNSVCTTKTSTRIVGG TNSSWGEWPWQVSLQ VKLTAQRHLCGGSLIGHQWVLTAAH CFDGLPLQDVWRIYSGILNLSDITK DTPFSQIKEIIIHQN YKVSEGNHDIALIKLQAPLNYTEFQ KPICLPSKGDTSTIYTNCWVTGWGF SKEKGEIQNILQKVN IPLVTNEECQKRYQDYKITQRMVCA GYKEGGKDACKGDSGGPLVCKHNGM WRLVGITSWGEGCAR REQPGVYTKVAEYMDWILEKTQSSD GKAQMQSPAVDHHHHHH
Endotoxin : Less than 0.1 ng/µg (1 IEU/µg) as determined by LAL test.
Purity : Greater than 95% as determined by reducing SDS-PAGE.
Storage : Store at < -20 centigrade, stable for 6 months after receipt.
Please minimize freeze-thaw cycles.
Shipping : The product is shipped on dry ice/ice packs.
Gene Name : KLKB1 kallikrein B, plasma (Fletcher factor) 1 [ Homo sapiens ]
Official Symbol : KLKB1
Synonyms : KLKB1; kallikrein B, plasma (Fletcher factor) 1; KLK3; plasma kallikrein; kininogenin; Fletcher factor; plasma prekallikrein; plasma kallikrein heavy chain; plasma kallikrein light chain; PPK;
Gene ID : 3818
mRNA Refseq : NM_000892
Protein Refseq : NP_000883
MIM : 229000
UniProt ID : P03952
Chromosome Location : 4q35
Pathway : Activation of Matrix Metalloproteinases, organism-specific biosystem; Blood Clotting Cascade, organism-specific biosystem; Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; Degradation of the extracellular matrix, organism-specific biosystem; Extracellular matrix organization, organism-specific biosystem;
Function : peptidase activity; protein binding; serine-type endopeptidase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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