Recombinant Human KMT2A Complex, His-tagged

• Cat.No.: KMT2A-128H
• Product Overview: Recombinant Human MLL1(3745-3969), WDR5(22-334), RbBP5(1-538), Ash2L(2-534), DPY-30(1-99) protein, fused with N-terminal His-tag on all subunits, was expressed in E.coli.

Specification

• Source: E.coli
• Species: Human
• Tag: His
• Form: 20 mM Tris-HCl, pH 7.5, 300 mM NaCl, 1 mM TCEP (tris(2-carboxyethyl)phosphine HCl), 10% (w/v) glycerol, 1 µM ZnCl2.
• Molecular Mass: 212.0 kDa
• Purity: >90% by SDS-PAGE
• Storage: Store at -80°C. Thaw quickly and store on ice before use. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: KMT2A lysine (K)-specific methyltransferase 2A [ Homo sapiens ]
• Official Symbol: KMT2A
• Synonyms: HRX; MLL; MLL1; TRX1; ALL-1; CXXC7; HTRX1; MLL1A; WDSTS; MLL-AF9; MLL/GAS7; TET1-MLL; CDK6/MLL fusion protein; CXXC-type zinc finger protein 7; MLL-AF4 der(11) fusion protein; MLL/ENL fusion protein; MLL/GAS7 fusion protein; MLL/GMPS fusion protein; MLL/hCDCrel fusion protein; lysine N-methyltransferase 2A; mixed lineage leukemia 1; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); rearranged MLL protein; trithorax-like protein; zinc finger protein HRX
• Gene ID: 4297
• mRNA Refseq: NM_001197104
• Protein Refseq: NP_001184033
• MIM: 159555
• UniProt ID: Q03164
• Chromosome Location: 11q23
• Pathway: Chromatin modifying enzymes, organism-specific biosystem; Chromatin organization, organism-specific biosystem; Lysine degradation, conserved biosystem
• Function: AT DNA binding; chromatin binding; core promoter sequence-specific DNA binding