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Recombinant Human MAX protein, MYC/DDK-tagged

Cat.No. : MAX-173H
Product Overview : Recombinant Human MAX, transcript variant 3, fused with MYC/DDK tag at C-terminal was expressed in HEK293.
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Description : The protein encoded by this gene is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors. It is able to form homodimers and heterodimers with other family members, which include Mad, Mxi1 and Myc. Myc is an oncoprotein implicated in cell proliferation, differentiation and apoptosis. The homodimers and heterodimers compete for a common DNA target site (the E box) and rearrangement among these dimer forms provides a complex system of transcriptional regulation. Mutations of this gene have been reported to be associated with hereditary pheochromocytoma. A pseudogene of this gene is located on the long arm of chromosome 7. Alternative splicing results in multiple transcript variants.
Source : HEK293
Species : Human
Tag : MYC/DDK
Form : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass : 11.9 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : MAX MYC associated factor X [ Homo sapiens ]
Official Symbol : MAX
Synonyms : MAX; MYC associated factor X; MAX protein; protein max; bHLHd4; bHLHd5; bHLHd6; bHLHd7; bHLHd8; helix-loop-helix zipper protein; class D basic helix-loop-helix protein 4; orf1; MGC10775; MGC11225; MGC18164; MGC34679; MGC36767;
Gene ID : 4149
mRNA Refseq : NM_145113
Protein Refseq : NP_660088
MIM : 154950
UniProt ID : P61244
Chromosome Location : 14q23
Pathway : C-MYC pathway, organism-specific biosystem; Cell Cycle, organism-specific biosystem; Cell Cycle, Mitotic, organism-specific biosystem; Cyclin A:Cdk2-associated events at S phase entry, organism-specific biosystem; Cyclin E associated events during G1/S transition, organism-specific biosystem; G1/S Transition, organism-specific biosystem; MAPK signaling pathway, organism-specific biosystem;
Function : protein binding; protein complex binding; protein heterodimerization activity; protein homodimerization activity; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription coactivator activity; transcription cofactor activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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How to evaluate the potential of MAX proteins as drug targets? 07/16/2022

Evaluating the potential of MAX proteins as drug targets can involve several aspects, including their expression levels in organisms, their role in biological processes, and their changes in disease. In addition, factors such as ease of drug development for this protein and potential drug side effects need to be considered.

What is the function of MAX proteins? 02/05/2022

The function of MAX proteins may be related to their localization and structure within the cell. It may be a nuclear protein that regulates the transcription of specific genes by binding to DNA. In addition, it may also regulate processes such as cell signaling and cell proliferation by interacting with other proteins.

What are the effects of mutations or modifications in MAX proteins on organisms? 12/04/2020

Mutations or modifications of MAX proteins may affect their function and thus on the organism. The specific effects may vary depending on the type and location of the mutation or modification and may involve various biological processes, such as growth and development, immune response, etc.

What biological processes does MAX protein play a role in? 11/26/2020

MAX proteins may be involved in a variety of biological processes, including cell proliferation, cell differentiation, apoptosis, etc. It may influence tumorigenesis and progression by modulating these processes.

How is the expression level of MAX protein regulated? 10/06/2020

The expression level of MAX protein may be regulated by a variety of factors, including gene transcription, translation, post-transcriptional modification, etc. Studying these regulatory mechanisms can help to understand the expression patterns of MAX proteins in organisms and their effects on biological processes.

How does MAX protein interact with other proteins? 05/28/2020

MAX proteins may interact with other proteins to fulfill their functions. These interactions can involve various types of protein-protein interactions like electrostatic interactions, hydrogen bonding, etc. Understanding these interactions can help uncover the mechanism of action of MAX proteins in cells.

Customer Reviews (3)

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Reviews
07/16/2023

    Greatly improve the rate and selectivity of chemical reactions, and its scientific research value is incomparable.

    05/14/2023

      MAX has excellent labeling results and can be used for a wide range of experimental methods, such as fluorescent labeling.

      06/11/2021

        The high catalytic efficiency, high safety, and high expression level make the experimental results extremely confident.

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