Recombinant Human MBP protein, MYC/DDK-tagged
Cat.No. : | MBP-9382H |
Product Overview : | Recombinant Human MBP, transcript variant 1, fused with MYC/DDK tag at C-terminal was expressed in HEK293. |
- Specification
- Gene Information
- Related Products
Source : | HEK293 |
Species : | Human |
Tag : | MYC/DDK |
Form : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Molecular Mass : | 21.3 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Concentration : | >50 ug/mL as determined by microplate BCA method |
Gene Name : | MBP myelin basic protein [ Homo sapiens ] |
Official Symbol : | MBP |
Synonyms : | MBP; myelin basic protein; Golli-MBP; myelin basic protein; myelin A1 protein; myelin membrane encephalitogenic protein; MGC99675; |
Gene ID : | 4155 |
mRNA Refseq : | NM_001025081 |
Protein Refseq : | NP_001020252 |
MIM : | 159430 |
UniProt ID : | P02686 |
Chromosome Location : | 18q23 |
Pathway : | MAPK Cascade, organism-specific biosystem; |
Function : | structural constituent of myelin sheath; |
Products Types
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MBP-2527H | Recombinant Human MBP protein(101-190 aa), C-His-tagged | +Inquiry |
◆ Native Protein | ||
MBP-6949M | Native Mouse Myelin basic protein | +Inquiry |
MBP-99S | Native Swine MBP | +Inquiry |
MBP-89S | Native Swine MBP Protein | +Inquiry |
◆ Lysates | ||
MBP-4438HCL | Recombinant Human MBP 293 Cell Lysate | +Inquiry |
MBP-4436HCL | Recombinant Human MBP 293 Cell Lysate | +Inquiry |
MBP-4437HCL | Recombinant Human MBP 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (7)
Ask a questionThe MBP gene encodes the Myelin Basic Protein, which is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system.
MBP expression is tightly regulated during neural development. It increases as oligodendrocytes differentiate and begin to form the myelin sheath around axons.
In multiple sclerosis (MS), an autoimmune disease, MBP is one of the targets for immune cells. The immune system attacks and degrades the myelin sheath, leading to the characteristic symptoms of MS.
Other than MS, demyelinating diseases like Pelizaeus-Merzbacher disease and some leukodystrophies can be linked to issues with MBP. These conditions can lead to a range of neurological symptoms due to impaired nerve transmission.
Therapeutic strategies targeting MBP mainly focus on preventing the immune system from attacking it, especially in the context of MS. This includes the development of immunomodulatory drugs and therapies to promote remyelination.
Beyond MS, mutations or dysregulation of MBP can lead to other rare demyelinating diseases and some forms of leukodystrophy.
MBP plays a crucial role in the formation of the myelin sheath, a fatty layer that insulates nerve fibers. It helps compact and stabilize the layers of myelin, ensuring efficient nerve signal transmission.
Customer Reviews (3)
Write a reviewProduct exactly as described.
Worked well in ELISA.
Excellent customer support, helpful.
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