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Recombinant Human MBP protein, MYC/DDK-tagged

Cat.No. : MBP-9382H
Product Overview : Recombinant Human MBP, transcript variant 1, fused with MYC/DDK tag at C-terminal was expressed in HEK293.
  • Specification
  • Gene Information
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Source : HEK293
Species : Human
Tag : MYC/DDK
Form : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass : 21.3 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : MBP myelin basic protein [ Homo sapiens ]
Official Symbol : MBP
Synonyms : MBP; myelin basic protein; Golli-MBP; myelin basic protein; myelin A1 protein; myelin membrane encephalitogenic protein; MGC99675;
Gene ID : 4155
mRNA Refseq : NM_001025081
Protein Refseq : NP_001020252
MIM : 159430
UniProt ID : P02686
Chromosome Location : 18q23
Pathway : MAPK Cascade, organism-specific biosystem;
Function : structural constituent of myelin sheath;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What is the primary function of the MBP gene and its encoded protein? 09/30/2022

The MBP gene encodes the Myelin Basic Protein, which is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system.

How is MBP expression regulated during neural development? 01/11/2021

MBP expression is tightly regulated during neural development. It increases as oligodendrocytes differentiate and begin to form the myelin sheath around axons.

What role does MBP play in multiple sclerosis (MS)? 09/29/2020

In multiple sclerosis (MS), an autoimmune disease, MBP is one of the targets for immune cells. The immune system attacks and degrades the myelin sheath, leading to the characteristic symptoms of MS.

What are the implications of MBP in demyelinating diseases beyond MS? 09/20/2019

Other than MS, demyelinating diseases like Pelizaeus-Merzbacher disease and some leukodystrophies can be linked to issues with MBP. These conditions can lead to a range of neurological symptoms due to impaired nerve transmission.

Are there any therapeutic strategies targeting MBP or its pathways in neurodegenerative diseases? 04/30/2019

Therapeutic strategies targeting MBP mainly focus on preventing the immune system from attacking it, especially in the context of MS. This includes the development of immunomodulatory drugs and therapies to promote remyelination.

Are there any known diseases or conditions associated with mutations or dysregulation of MBP? 03/12/2019

Beyond MS, mutations or dysregulation of MBP can lead to other rare demyelinating diseases and some forms of leukodystrophy.

How does MBP contribute to the structure and function of myelin sheaths in the nervous system? 07/14/2018

MBP plays a crucial role in the formation of the myelin sheath, a fatty layer that insulates nerve fibers. It helps compact and stabilize the layers of myelin, ensuring efficient nerve signal transmission.

Customer Reviews (3)

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Reviews
12/21/2019

    Product exactly as described.

    07/27/2018

      Worked well in ELISA.

      05/13/2018

        Excellent customer support, helpful.

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