Recombinant Human MYD88 protein, MYC/DDK-tagged
Cat.No. : | MYD88-30H |
Product Overview : | Recombinant Human MYD88 fused with MYC/DDK tag at C-terminal was expressed in HEK293. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants. |
Source : | HEK293 |
Species : | Human |
Tag : | MYC/DDK |
Form : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Molecular Mass : | 33.1 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Concentration : | >50 ug/mL as determined by microplate BCA method |
Gene Name : | MYD88 myeloid differentiation primary response gene (88) [ Homo sapiens ] |
Official Symbol : | MYD88 |
Synonyms : | MYD88; myeloid differentiation primary response gene (88); myeloid differentiation primary response protein MyD88; MYD88D; |
Gene ID : | 4615 |
mRNA Refseq : | NM_002468 |
Protein Refseq : | NP_002459 |
MIM : | 602170 |
UniProt ID : | Q99836 |
Chromosome Location : | 3p22 |
Function : | TIR domain binding; Toll binding; death receptor binding; identical protein binding; protein binding; |
Products Types
◆ Recombinant Protein | ||
MYD88-2737R | Recombinant Rhesus Macaque MYD88 Protein, His (Fc)-Avi-tagged | +Inquiry |
MYD88-1147C | Recombinant Chicken MYD88 Protein, His-tagged | +Inquiry |
MYD88-3502R | Recombinant Rat MYD88 Protein, His (Fc)-Avi-tagged | +Inquiry |
MYD88-0071H | Recombinant Human MYD88 Protein (M157-P296), Tag Free | +Inquiry |
MYD88-0072H | Recombinant Human MYD88 Protein (M157-P296), His/GST tagged | +Inquiry |
◆ Lysates | ||
MYD88-4034HCL | Recombinant Human MYD88 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionMYD88 recruits IRAK kinases to form the Myddosome complex, initiating a signaling cascade that culminates in the activation of NF-κB and pro-inflammatory gene expression.
MYD88 expression is tightly regulated at the transcriptional level by various factors, including transcription factors and epigenetic modifications.
MYD88 is a key mediator in the recognition of microbial components by TLRs, initiating signaling cascades that trigger immune responses against pathogens.
MYD88 activates NF-κB and MAPK signaling pathways, leading to the production of pro-inflammatory cytokines and interferons that orchestrate immune responses.
MYD88 plays a role in shaping adaptive immune responses by influencing the activation and differentiation of T and B cells, promoting an effective immune defense.
Customer Reviews (3)
Write a reviewTop-tier service—customer support's expertise ensured the perfect protein fit.
Dependable quality and service—this recombined protein is a lab favorite.
Rapid delivery, precise results—this product is a lab essential.
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