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Recombinant Human MYD88 protein, MYC/DDK-tagged

Cat.No. : MYD88-30H
Product Overview : Recombinant Human MYD88 fused with MYC/DDK tag at C-terminal was expressed in HEK293.
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Description : This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants.
Source : HEK293
Species : Human
Tag : MYC/DDK
Form : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass : 33.1 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : MYD88 myeloid differentiation primary response gene (88) [ Homo sapiens ]
Official Symbol : MYD88
Synonyms : MYD88; myeloid differentiation primary response gene (88); myeloid differentiation primary response protein MyD88; MYD88D;
Gene ID : 4615
mRNA Refseq : NM_002468
Protein Refseq : NP_002459
MIM : 602170
UniProt ID : Q99836
Chromosome Location : 3p22
Function : TIR domain binding; Toll binding; death receptor binding; identical protein binding; protein binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does MYD88 contribute to the formation of the Myddosome complex in TLR signaling? 12/13/2021

MYD88 recruits IRAK kinases to form the Myddosome complex, initiating a signaling cascade that culminates in the activation of NF-κB and pro-inflammatory gene expression.

How is the expression of the MYD88 gene regulated at the molecular level? 06/26/2020

MYD88 expression is tightly regulated at the transcriptional level by various factors, including transcription factors and epigenetic modifications.

Explain the role of MYD88 in the recognition of microbial components by the immune system. 03/09/2019

MYD88 is a key mediator in the recognition of microbial components by TLRs, initiating signaling cascades that trigger immune responses against pathogens.

What are the downstream signaling pathways activated by MYD88, and how do they influence immune responses? 10/26/2018

MYD88 activates NF-κB and MAPK signaling pathways, leading to the production of pro-inflammatory cytokines and interferons that orchestrate immune responses.

Explain the role of MYD88 in adaptive immunity and its crosstalk with T and B cell responses. 05/01/2018

MYD88 plays a role in shaping adaptive immune responses by influencing the activation and differentiation of T and B cells, promoting an effective immune defense.

Customer Reviews (3)

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Reviews
02/26/2022

    Top-tier service—customer support's expertise ensured the perfect protein fit.

    01/09/2019

      Dependable quality and service—this recombined protein is a lab favorite.

      05/23/2018

        Rapid delivery, precise results—this product is a lab essential.

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