Recombinant Human NRG4 Protein
Cat.No. : | NRG4-452H |
Product Overview : | Recombinant human NRG4 (Q8WWG1) extracellular domain (Pro 2-Phe 62) was expressed and purified, with additional two amino acids (Gly & Pro) at the N-terminus. |
- Specification
- Gene Information
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Source : | E. coli |
Species : | Human |
Predicted N Terminal : | Gly |
Form : | Lyophilized from sterile 50mM Tris, 50mM NaCl, pH 7.2, 5%~8% trehalose and mannitol. |
Molecular Mass : | The recombinant human NRG4 consists of 63 amino acids and has a calculated molecular mass of 6.7 KDa as estimated in SDS-PAGE under reducing conditions. |
Endotoxin : | < 1.0 EU per μg of the protein as determined by the LAL method. |
Purity : | >92 % as determined by SDS-PAGE. |
Stability : | Samples are stable for up to twelve months from date of receipt at -70ºC. |
Storage : | Store it under sterile conditions at -20ºC~-70ºC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.25 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents. |
Gene Name : | NRG4 neuregulin 4 [ Homo sapiens ] |
Official Symbol : | NRG4 |
Synonyms : | NRG4; neuregulin 4; pro-neuregulin-4, membrane-bound isoform; HRG4; pro-NRG4; heregulin 4; DKFZp779N0541; DKFZp779N1944; |
Gene ID : | 145957 |
mRNA Refseq : | NM_138573 |
Protein Refseq : | NP_612640 |
MIM : | 610894 |
UniProt ID : | Q8WWG1 |
Chromosome Location : | 15q23 |
Pathway : | ErbB receptor signaling network, organism-specific biosystem; ErbB signaling pathway, organism-specific biosystem; ErbB signaling pathway, organism-specific biosystem; ErbB signaling pathway, conserved biosystem; ErbB4 signaling events, organism-specific biosystem; GRB2 events in ERBB2 signaling, organism-specific biosystem; Nuclear signaling by ERBB4, organism-specific biosystem; |
Products Types
◆ Recombinant Protein | ||
NRG4-167 | Recombinant NRG4 Protein, GST-tagged | +Inquiry |
NRG4-07H | Active Recombinant Human NRG4 Protein | +Inquiry |
NRG4-365H | Recombinant Human NRG4 Protein, His/GST-tagged | +Inquiry |
NRG4-6200M | Recombinant Mouse NRG4 Protein, His (Fc)-Avi-tagged | +Inquiry |
Nrg4-01M | Active Recombinant Mouse Nrg4 Protein, GST-tagged | +Inquiry |
◆ Lysates | ||
NRG4-1221HCL | Recombinant Human NRG4 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionThe function of NRG4 can be studied through overexpression techniques, such as the use of gene transfection or viral transduction. These techniques can increase the expression level of NRG4 to observe its effects on cell growth, differentiation, and survival, among other things.
It has a variety of roles in tissues such as the heart, nerves, and muscles, including promoting cell growth, differentiation, and survival, as well as regulating synaptic plasticity and nerve signaling.
In the heart, NRG4 can promote cardiomyocyte growth and survival, maintain cardiomyocyte electrophysiological properties, and regulate cardiac rhythms.
Immunohistochemistry, western blotting, and real-time PCR can be used to detect NRG4 expression levels in tissues and cells. These techniques can be used to assess NRG4 expression in different tissues and cells.
NRG4 activates receptor phosphorylation by interacting with its receptors ErbB3 and ErbB4, which in turn triggers intracellular signaling pathways.
The interaction between NRG4 and other proteins is regulated by a variety of mechanisms, including through the formation of complexes, through interaction motifs at the interface of protein interactions, and by regulating conformational changes of proteins. These interactions can be modulated to achieve specific physiological functions.
Customer Reviews (3)
Write a reviewNRG4 had the intended biological effect in the experiment.
The experimental results using NRG4 are accurate and reliable, and the data are scientific.
NRG4's products have been widely recognized and applied in the research of related fields.
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