Recombinant Human PARK2 protein, His-tagged, Active
Cat.No. : | PARK2-421H |
Product Overview : | Recombinant full length Human PARK2 fused with His tag at N-terminal was expressed in Insect cells. Purified using immobilizedmetal affinity chromatography. |
- Specification
- Gene Information
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Description : | Parkin is an E3-ubiquitin ligase belonging to the RBR (RING – In Between RING – RING) family. Mutations in Parkin that result in a loss-of-function are the most frequent cause of familial Parkinson’s disease and are responsible for a large percentage of autosomal recessive juvenile parkinsonism (AR-JP). In addition to its auto-ubiquitination, Parkin can also ubiquitinate various substrates, including the CDK2-interacting protein cyclin E1, the a-synuclein-interacting protein synphilin-1, the synaptic vesicle-associated CDC-rel1 and the p38 subunit of aminoacyl-tRNA synthetase/JTV-1. Ubiquitination of substrates occurs in conjunction with the E2 enzymes UbcH7, UbcH8 or UbcH13/Uev1. |
Source : | Insect cells |
Species : | Human |
Tag : | His |
Form : | In 50mM Tris/HCl pH7.5, 150mM NaCl, 0.03% Brij-35, 270mM sucrose, 1mM benzamidine, 0.2mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution. |
Molecular Mass : | 55 kDa |
Purity : | 91% by SDS-PAGE and Coomassie blue staining |
Applications : | For use in Enzyme Assays. |
Notes : | Rapidly thaw the vial under cold water and immediately place on ice. Aliquot unused material into pre-chilled microcentrifuge tubes and immediately snap-freeze the vials in liquid nitrogen prior to re-storage at -70 centigrade. |
Storage : | Estimated to be stable for a minimum of 1 year at -70 centigrade from date of shipment. For maximum recovery of product, centrifuge original vial prior to removing the cap. |
Concentration : | 1.214 mg/ml |
Gene Name : | PARK2 parkinson protein 2, E3 ubiquitin protein ligase (parkin) [ Homo sapiens ] |
Official Symbol : | PARK2 |
Synonyms : | PARK2; parkinson protein 2, E3 ubiquitin protein ligase (parkin); Parkinson disease (autosomal recessive, juvenile) 2, parkin; E3 ubiquitin-protein ligase parkin; AR JP; E3 ubiquitin ligase; parkin; PDJ; parkin 2; parkinson disease protein 2; parkinson juvenile disease protein 2; PRKN; AR-JP; LPRS2; |
Gene ID : | 5071 |
mRNA Refseq : | NM_004562 |
Protein Refseq : | NP_004553 |
MIM : | 602544 |
UniProt ID : | O60260 |
Chromosome Location : | 6q25.2-q27 |
Pathway : | Adaptive Immune System, organism-specific biosystem; Alpha-synuclein signaling, organism-specific biosystem; Antigen processing: Ubiquitination and Proteasome degradation, organism-specific biosystem; Class I MHC mediated antigen processing & presentation, organism-specific biosystem; Immune System, organism-specific biosystem; |
Function : | PDZ domain binding; acid-amino acid ligase activity; chaperone binding; kinase binding; ligase activity; metal ion binding; protein binding; protein kinase binding; ubiquitin protein ligase binding; ubiquitin-protein ligase activity; zinc ion binding; |
Products Types
◆ Recombinant Protein | ||
PARK2-516C | Recombinant Cynomolgus Monkey PARK2 Protein, His (Fc)-Avi-tagged | +Inquiry |
PARK2-6497M | Recombinant Mouse PARK2 Protein, His (Fc)-Avi-tagged | +Inquiry |
PARK2-3935R | Recombinant Rat PARK2 Protein, His (Fc)-Avi-tagged | +Inquiry |
PARK2-11H | Recombinant Human PARK2 protein, His-tagged | +Inquiry |
PARK2-30784TH | Recombinant Human PARK2 | +Inquiry |
◆ Lysates | ||
PARK2-3433HCL | Recombinant Human PARK2 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionBesides Parkinson's disease, PARK2 mutations have been linked to other neurodegenerative disorders, expanding the clinical implications of studying this protein.
Yes, drug development efforts are underway to modulate PARK2 activity and enhance its neuroprotective functions as a potential therapeutic approach for Parkinson's disease.
PARK2 research provides crucial insights into the role of mitochondrial dynamics in neurodegenerative diseases, helping unravel the mechanisms underlying these disorders and paving the way for targeted therapies.
Genetic testing can help identify individuals with PARK2 mutations, allowing for personalized treatment strategies tailored to their specific genetic profile.
PARK2 is implicated in controlling inflammation in the brain, and its dysfunction may contribute to neuroinflammatory processes observed in Parkinson's disease.
Customer Reviews (3)
Write a reviewTheir expertise and commitment to customer satisfaction make them a trusted partner in achieving research goals.
Their knowledgeable team is readily available to address any questions or concerns, guaranteeing a smooth experimental process.
the manufacturer of PARK2 protein provides excellent technical support, ensuring prompt assistance and guidance.
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