Recombinant Human PDCD4 Protein, His-tagged
Cat.No. : | PDCD4-484H |
Product Overview : | Recombinant Human PDCD4, transcript variant 1, fused with His tag at C-terminal was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
Description : | THis gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants |
Source : | E. coli |
Tag : | His |
Form : | Lyophilized from a 0.2 µM filtered solution of PBS, pH 7.4 |
Molecular Mass : | 17kD |
AA Sequence : | MKASHREMTSKLLSDLCGTVMSTTD VEKSFDKLLKDLPELALDTPRAPQL VGQFIARAVGDGILCNTYIDSYKGT VDCVQARAALDKATVLLSMSKGGKR KDSVWGSGGGQQSVNHLVKEIDMLL KEYLLSGDISEAEHCLKELEVPLEH HHHHH |
Endotoxin : | Endotoxin level is <0.1 ng/µg of protein (<1EU/µg). |
Purity : | >95% as determined by SDS-PAGE and Coomassie blue staining |
Concentration : | Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 µg/ml. Dissolve the lyophilized protein in 1X PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
Gene Name : | PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) [ Homo sapiens ] |
Official Symbol : | PDCD4 |
Synonyms : | PDCD4; programmed cell death 4 (neoplastic transformation inhibitor); programmed cell death protein 4; H731; nuclear antigen H731; protein 197/15a; neoplastic transformation inhibitor protein; MGC33046; MGC33047; |
Gene ID : | 27250 |
mRNA Refseq : | NM_001199492 |
Protein Refseq : | NP_001186421 |
MIM : | 608610 |
UniProt ID : | Q53EL6 |
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◆ Lysates | ||
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionYes, PDCD4 is involved in the regulation of NF-κB signaling pathway and other biological processes of sequencing signals, and can be a target for sequencing signals.
Immunodeficiency method, Western blot, fluorescence microscopy and other techniques can be used to evaluate the changes in the expression and function of PDCD4.
It may be involved in processes such as proliferation, apoptosis, and inflammatory response of intestinal epithelial cells, and is associated with intestinal diseases.
PDCD4 may be related to neuronal apoptosis, neuroinflammatory response, etc. in neurological diseases.
PDCD4 is involved in the regulation of hepatocyte growth, apoptosis and transformation, and may play a role in the occurrence and development of liver diseases.
Through in-depth study of the signaling pathways and regulatory mechanisms of PDCD4, we can provide important clues for the development of therapeutic strategies for related diseases.
Customer Reviews (3)
Write a reviewGood solubility and stability in solution.
The purity is good, and the results obtained after analysis by SDS-PAGE or Western blot are good.
Short half-life and high clearance.
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