Recombinant Human PRMT5/WDR77 protein, FLAG/His-tagged
Cat.No. : | PRMT5-32H |
Product Overview : | Recombinant Human PRMT5/WDR77(a.a: 2–end (both)) fused with N-terminal FLAG-tag (PRMT5) and N-terminal His-tag (WDR77) was expressed in FreeStyle 293-F cells. |
- Specification
- Gene Information
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Description : | Three types of arginine methylation exist in mammalian cells: monomethylarginine (MMA), asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA). Type I PRMTs ((CARM1, PRMT1, PRMT2, PRMT3, PRMT6, and PRMT8) catalyze ADMA, while type II PRMTs (e.g. PRMTs 5 and 7) catalyze SDMA. Type II PRMTs are found to be strongly implicated in diseases like cancer. For example, PRMT5 plays a role in the repression of certain tumor suppressor genes such as RB tumor suppressors while PRMT7 overex |
Source : | HEK293 |
Species : | Human |
Tag : | FLAG/His |
Form : | 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 3 mM DTT, 80 µg/ml Flag peptide, and 20% glycerol. |
Molecular Mass : | 73 kDa (PRMT5), 37.5 kDa (MEP50) |
Purity : | >75% |
Applications : | Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. |
Storage : | At least 6 months at -80 centigrade. Avoid freeze/thaw cycles. |
Gene Name : | PRMT5 protein arginine methyltransferase 5 [ Homo sapiens ] |
Official Symbol : | PRMT5 |
Synonyms : | PRMT5; protein arginine methyltransferase 5; HRMT1L5, SKB1, skb1 (S. pombe) homolog , SKB1 homolog (S. pombe); protein arginine N-methyltransferase 5; SKB1Hs; SKB1 homolog; jak-binding protein 1; 72 kDa ICln-binding protein; HMT1 hnRNP methyltransferase-like 5; shk1 kinase-binding protein 1 homolog; histone-arginine N-methyltransferase PRMT5; JBP1; SKB1; IBP72; HRMT1L5; |
Gene ID : | 10419 |
mRNA Refseq : | NM_006109 |
Protein Refseq : | NP_006100 |
MIM : | 604045 |
UniProt ID : | O14744 |
Chromosome Location : | 14q11.2 |
Pathway : | E2F transcription factor network, organism-specific biosystem; Gene ex |
Function : | histone-arginine N-methyltransferase activity; methyltransferase activity; protein binding; protein-arginine omega-N symmetric methyltransferase activity; ribonucleoprotein complex binding; transferase activity; |
Products Types
◆ Recombinant Protein | ||
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PRMT5-7125M | Recombinant Mouse PRMT5 Protein, His (Fc)-Avi-tagged | +Inquiry |
Prmt5-5133M | Recombinant Mouse Prmt5 Protein, Myc/DDK-tagged | +Inquiry |
PRMT5-1771H | Recombinant Human PRMT5 Protein, His (Fc)-Avi-tagged | +Inquiry |
PRMT5-3004H | Recombinant Human PRMT5 Protein, MYC/DDK-tagged | +Inquiry |
◆ Lysates | ||
PRMT5-2577HCL | Recombinant Human PRMT5 cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-1858 | PRMT5 Chemiluminescent Assay Kit | +Inquiry |
Kit-1859 | PRMT5 Homogeneous Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
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Q&As (5)
Ask a questionYes, there are ongoing clinical trials investigating the efficacy of PRMT5 inhibitors in various cancer types.
PRMT5 influences cellular differentiation by regulating the expression of genes involved in the process.
Yes, there is interest in exploring combination therapies involving PRMT5 inhibitors with other anticancer agents to enhance treatment efficacy.
PRMT5 methylates histone proteins, leading to changes in chromatin structure and gene expression, thus playing a crucial role in epigenetic regulation.
PRMT5 has been implicated in neurodegenerative diseases, and understanding its role may provide insights into developing therapies for conditions like Alzheimer's and Parkinson's disease.
Customer Reviews (3)
Write a reviewGreat performance in ELISA.
Its purity and functionality ensure precise and reproducible results, enabling me to achieve my research objectives with confidence.
The PRMT5 protein demonstrates exceptional quality, making it an ideal candidate to fulfill my experimental requirements.
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