Active Recombinant Human PTPN6 protein, His-tagged
Cat.No. : | PTPN6-289H |
Product Overview : | Recombinant Human PTPN6 fused with His tag at C-terminal was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
Description : | PTPN6 gene is preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. The noncatalytic N-terminus of this PTP can interact with MAP kinases and negatively regulates ERK2 and p38 MAP-kinases activity. The PTPN6 was shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which was thought to function through dephosphorylating the molecules related to MAP kinase pathway. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol. |
Bio-activity : | 2500 nmol/min/mg |
Molecular Mass : | 67 kDa |
Purity : | > 95% |
Applications : | Phosphatase Assay, Western Blot |
Stability : | 1 year at -70 centigrade from the date of shipment. |
Storage : | Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Gene Name : | PTPN6 protein tyrosine phosphatase, non-receptor type 6 [ Homo sapiens ] |
Official Symbol : | PTPN6 |
Synonyms : | PTPN6; protein tyrosine phosphatase, non-receptor type 6; tyrosine-protein phosphatase non-receptor type 6; HCP; HCPH; PTP 1C; SHP 1; SHP1; hematopoietic cell phosphatase; protein-tyrosine phosphatase 1C; protein-tyrosine phosphatase SHP-1; hematopoietic cell protein-tyrosine phosphatase; SHP-1; HPTP1C; PTP-1C; SHP-1L; SH-PTP1; |
Gene ID : | 5777 |
mRNA Refseq : | NM_080548 |
Protein Refseq : | NP_536858 |
MIM : | 176883 |
UniProt ID : | P29350 |
Chromosome Location : | 12p13.31 |
Pathway : | Adaptive Immune System, organism-specific biosystem; Adherens junction, organism-specific biosystem; Adherens junction, conserved biosystem; B Cell Receptor Signaling Pathway, organism-specific biosystem; B cell receptor signaling pathway, organism-specific biosystem; B cell receptor signaling pathway, conserved biosystem; BCR signaling pathway, organism-specific biosystem; |
Function : | hydrolase activity; protein binding; protein kinase binding; protein tyrosine phosphatase activity; transmembrane receptor protein tyrosine phosphatase activity; |
Products Types
◆ Recombinant Protein | ||
PTPN6-1802H | Recombinant Human PTPN6 Protein, His (Fc)-Avi-tagged | +Inquiry |
PTPN6-0697H | Recombinant Human PTPN6 Protein (M1-K595), Tag Free | +Inquiry |
PTPN6-3129H | Recombinant Human PTPN6 Protein, MYC/DDK-tagged | +Inquiry |
PTPN6-4494R | Recombinant Rat PTPN6 Protein, His (Fc)-Avi-tagged | +Inquiry |
PTPN6-0698H | Recombinant Human PTPN6 Protein (M1-K595), His/Strep tagged | +Inquiry |
◆ Lysates | ||
PTPN6-001MCL | Recombinant Mouse PTPN6 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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