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Active Recombinant Human PVRIG protein, Fc-tagged

Cat.No. : PVRIG-188H
Product Overview : Recombinant Human PVRIG(Thr41 & Glu43­Leu172) fused with Fc region of Human IgG1 at C-terminal was expressed in HEK293.
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  • Gene Information
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Description : Human PVRIG (poliovirus receptor related immunoglobulin domain-containing protein), also known as CD112 receptor (CD112R), is an approximately 34 kDa single transmembrane protein in the poliovirus receptor-like protein (PVR) family. It is composed of a single extracellular IgV domain, one transmembrane domain, and a long intracellular domain. The intracellular domain contains two tyrosine residues, one within an ITIM-like motif that is a potential docking site for phosphatases. The extracellular domain sequence of human and mouse PVRIG have approximately 65% similarity. The human PVRIG gene is preferentially expressed in lymphocytes, such as T cells and NK cells, but not in monocyte derived dendritic cells. PVRIG functions as a cell surface receptor for Nectin-2/CD112, a cell surface protein that is widely expressed on antigen-presenting cells and tumor cells. Disrupting the PVRIG/Nectin-2 interaction enhances human T cell response, suggesting PVRIG is a novel checkpoint for human T cells.
Source : HEK293
Species : Human
Tag : Fc
Predicted N Terminal : Thr41 & Glu43
Form : Lyophilized from a 0.2 μm filtered solution in PBS. See Certificate of Analysis for details.
Bio-activity : Measured by its binding ability in a functional ELISA. When Recombinant Human PVRIG Fc Chimera is immobilized at 1 μg/mL, 100 μL/well, the concentration of Recombinant Human Nectin­2/CD112 that produces 50% of the optimal binding response is 0.4­2.4 μg/mL.
Molecular Mass : Predicted Molecular Mass: 40 kDa
SDS-PAGE: 51-57 kDa, reducing conditions
Endotoxin : <0.1 EU per 1 μg of the protein by the LAL method.
Purity : >95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Storage : Store the unopened product at -20 to -70 centigrade. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Reconstitution : Reconstitute at 500 μg/mL in PBS.
Gene Name : PVRIG poliovirus receptor related immunoglobulin domain containing [ Homo sapiens ]
Official Symbol : PVRIG
Synonyms : PVRIG; poliovirus receptor related immunoglobulin domain containing; transmembrane protein PVRIG; C7orf15; MGC2463; poliovirus receptor-related immunoglobulin domain-containing protein; MGC104322; MGC138295; MGC138297;
Gene ID : 79037
mRNA Refseq : NM_024070
Protein Refseq : NP_076975
UniProt ID : Q6DKI7

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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