Active Recombinant Human SERPINB5 protein

• Cat.No.: SERPINB5-193H
• Product Overview: Recombinant Human SERPINB5 was expressed in E. coli.

Specification

• Description: Mammary serine protease inhibitor (Maspin) is a non-inhibitory tumor suppressor serpin that is encoded by the SERPINB5 gene. Playing an important role in embryonic development in cell adhesion, Maspin has the ability to suppress the growth, invasion, and metastasis of breast and lung tumors. However, Maspin does not exhibit any serine protease inhibitor activity since it does not undergo the conformational transition from stressed to relaxed found in typical serpins. It is expressed in normal breast and prostatic epithelial cells, but downregulated in most breast carcinoma.
• Source: E. coli
• Species: Human
• Bio-activity: The ED (50) was determined by the dose-dependent proliferation of MDA-MB-468 cells and was found to be <0.05ng/mL.
• Molecular Mass: 42.3 kDa
• Endotoxin: <1.0 EU/μg of recombinant protein as determined by the LAL method.
• Purity: 95%
• Applications: Cell Assay
• Storage: The lyophilized protein is stable for at least one year from date of receipt at -70 centigrade. Upon reconstitution, this cytokine can be stored in working aliquots at 2 centigrade- 8 centigrade for one month, or at -20 centigrade for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.

Gene Information

• Gene Name: SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 [ Homo sapiens ]
• Official Symbol: SERPINB5
• Synonyms: SERPINB5; serpin peptidase inhibitor, clade B (ovalbumin), member 5; PI5, serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 5; serpin B5; maspin; protease inhibitor 5 (maspin); PI-5; peptidase inhibitor 5; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 5; PI5
• Gene ID: 5268
• mRNA Refseq: NM_002639
• Protein Refseq: NP_002630
• MIM: 154790
• UniProt ID: P36952
• Chromosome Location: 18q21.3
• Pathway: ATF-2 transcription factor network, organism-specific biosystem; Direct p53 effectors, organism-specific biosystem; p53 signaling pathway, organism-specific biosystem; p53 signaling pathway, conserved biosystem
• Function: protein binding; serine-type endopeptidase inhibitor activity