Recombinant Human SETD6 protein, GST-tagged

• Cat.No.: SETD6-261H
• Product Overview: Recombinant Human SETD6(1-473 aa) fused with GST tag at N-terminal was expressed in E. coli.

Specification

• Description: SETD6 is a SET-domain containing protein lysine methyltransferase, catalyzing the mono-methylation of RelA (p65, NFkB3) at lysine 310. Methylation of RelA attenuates RelA-dependant transcriptional pathways, including inflammatory responses in primary immune cells. SETD6 is downregulated in a diseases of hyper inflammation.
• Source: E. coli
• Species: Human
• Tag: GST
• Form: 100 mM Tris pH 8.0, 10mM glutathione and 25% glycerol.
• Molecular Mass: 72 kDa
• Applications: Recombinant SETD6, human is useful for RelA/p65 methylation experiments, enzyme kinetics and inhibitor screening. Use of 2-5 µg SETD6 per reaction with 1 µg recombinant RelA as a substrate is recommended.
• Storage: Stable for six months at -80 centigrade from date of receipt. For best results, aliquot and avoid multiple freeze/thaws.
• Concentration: 2.2 µg/µl

Gene Information

• Gene Name: SETD6 SET domain containing 6 [ Homo sapiens ]
• Official Symbol: SETD6
• Synonyms: SETD6; SET domain containing 6; N-lysine methyltransferase SETD6; FLJ21148; SET domain-containing protein 6
• Gene ID: 79918
• mRNA Refseq: NM_001160305
• Protein Refseq: NP_001153777
• UniProt ID: Q8TBK2
• Chromosome Location: 16q21