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Recombinant Human SNRNP70 protein

Cat.No. : SNRNP70-227H
Product Overview : Recombinant Human SNRNP70 was expressed in E. coli.
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Source : E. coli
Species : Human
Form : U1-snRNP is supplied in 20mM HEPES buffer pH-7.5, 0.01mM EDTA and 0.02% SDS.
Molecular Mass : Recombinant Human U1-snRNP 68kDa cDNA codes for the 70kDa isoform of the human U1-snRNP 68 protein (lacking 66 internal amino acids outside the known epitope-containing areas) fused to a hexahistidine purification tag.
The Calculated molecular weight is 44.8 kDa (U1-snRNP 68 displays aberrant electrophoretic mobility leading to an apparent discrepancy between calculated molecular weight and the 55-56 kDa molecular weight determined for this internally shortened molecule by SDS gel electrophoresis).
Purity : Greater than 90% as determined by SDS-PAGE.
Applications : Western-Blot with monoclonal anti-hexa-His-tag antibody & MCTD sera (Mixed Connective Tissue Disease).
Storage : Store at 4 centigrade if entire vial will be used within 2-4 weeks.
Store, frozen at -20 centigrade for longer periods of time.
Avoid multiple freeze-thaw cycles.
Publication :
Cohesin regulates alternative splicing (2023)
Gene Name : SNRNP70 small nuclear ribonucleoprotein 70kDa (U1) [ Homo sapiens ]
Official Symbol : SNRNP70
Synonyms : SNRNP70; small nuclear ribonucleoprotein 70kDa (U1); RNPU1Z, RPU1, small nuclear ribonucleoprotein 70kDa (RNP antigen) , SNRP70; U1 small nuclear ribonucleoprotein 70 kDa; Snp1; U1 70K; U1 snRNP 70 kDa; RPU1; U1AP; U170K; U1RNP; RNPU1Z; SNRP70; U1-70K;
Gene ID : 6625
mRNA Refseq : NM_003089
Protein Refseq : NP_003080
MIM : 180740
UniProt ID : P08621

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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How is SNRNP70 linked to autoimmune diseases? 05/05/2018

Autoantibodies against SNRNP70 are frequently found in individuals with autoimmune diseases, serving as a diagnostic marker for conditions like SLE.

Are there specific techniques used to detect anti-SNRNP70 antibodies? 08/23/2017

Common methods include immunoprecipitation, enzyme-linked immunosorbent assay (ELISA), and Western blotting.

Can changes in SNRNP70 levels be used to monitor treatment response in autoimmune diseases? 07/10/2017

Monitoring anti-SNRNP70 antibody levels during treatment may offer insights into the effectiveness of therapeutic interventions in autoimmune diseases.

How might SNRNP70 be a potential therapeutic target? 03/19/2017

Understanding the role of SNRNP70 in autoimmune diseases could lead to the development of targeted therapies aimed at modulating its activity.

Can anti-SNRNP70 antibodies be found in diseases other than SLE? 09/24/2016

Yes, anti-SNRNP70 antibodies are also associated with other autoimmune diseases such as mixed connective tissue disease (MCTD) and rheumatoid arthritis.

Customer Reviews (3)

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02/06/2022

    This may include providing detailed protocols, troubleshooting advice, and suggestions for experimental design.

    04/27/2019

      The manufacturer can provide researchers with high-quality ARMC6 protein, ensuring it is properly purified, characterized, and quality-controlled.

      12/17/2018

        This collaboration may extend beyond the purchase of the SNRNP70 protein, potentially leading to additional support, joint research projects, or access to expertise in the field.

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