Recombinant Human STAT3 protein, His-tagged
Cat.No. : | STAT3-316H |
Product Overview : | Recombinant Human STAT3 protein (full Length, 1-770aa) was expressd in Yeast with N-terminal 6xHis tag. |
- Specification
- Gene Information
- Related Products
Description : | Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elents identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. Cytoplasmic domain STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity. Plays an important role in host defense in methicillin-resistant S.aureus lung infection by regulating the expression of the antimicrobial lectin REG3G. |
Source : | Yeast |
Species : | Human |
Tag : | His |
Form : | Tris-based buffer, 50% glycerol. |
Molecular Mass : | 90kDa |
AA Sequence : | MAQWNQLQQLDTRYLEQLHQLYSDS FPMELRQFLAPWIESQDWAYAASKE SHATLVFHNLLGEIDQQYSRFLQES NVLYQHNLRRIKQFLQSRYLEKPME IARIVARCLWEESRLLQTAATAAQQ GGQANHPTAAVVTEKQQMLEQHLQD VRKRVQDLEQKMKVVENLQDDFDFN YKTLKSQGDMQDLNGNNQSVTRQKM QQLEQMLTALDQMRRSIVSELAGLL SAMEYVQKTLTDEELADWKRRQQIA CIGGPPNICLDRLENWITSLAESQL QTRQQIKKLEELQQKVSYKGDPIVQ HRPMLEERIVELFRNLMKSAFVVER QPCMPMHPDRPLVIKTGVQFTTKVR LLVKFPELNYQLKIKVCIDKDSGDV AALRGSRKFNILGTNTKVMNMEESN NGSLSAEFKHLTLREQRCGNGGRAN CDASLIVTEELHLITFETEVYHQGL KIDLETHSLPVVVISNICQMPNAWA SILWYNMLTNNPKNVNFFTKPPIGT WDQVAEVLSWQFSSTTKRGLSIEQL TTLAEKLLGPGVNYSGCQITWAKFC KENMAGKGFSFWVWLDNIIDLVKKY ILALWNEGYIMGFISKERERAILST KPPGTFLLRFSESSKEGGVTFTWVE KDISGKTQIQSVEPYTKQQLNNMSF AEIIMGYKIMDATNILVSPLVYLYP DIPKEEAFGKYCRPESQEHPEADPG SAAPYLKTKFICVTPTTCSNTIDLP MSPRTLDSLMQFGNNGEGAEPSAGG QFESLTFDMELTSECATSPM |
Purity : | Greater than 90% as determined by SDS-PAGE. |
Stability : | The shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade. |
Gene Name : | STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) [ Homo sapiens ] |
Official Symbol : | STAT3 |
Synonyms : | STAT3; signal transducer and activator of transcription 3 (acute-phase response factor); signal transducer and activator of transcription 3; APRF; DNA-binding protein APRF; acute-phase response factor; HIES; FLJ20882; MGC16063 |
Gene ID : | 6774 |
mRNA Refseq : | NM_003150 |
Protein Refseq : | NP_003141 |
MIM : | 102582 |
UniProt ID : | P40763 |
Products Types
◆ Recombinant Protein | ||
Stat3-2107R | Recombinant Rat Stat3 Protein, His-tagged | +Inquiry |
STAT3-138H | Recombinant Human STAT3 Protein, His-tagged | +Inquiry |
Stat3-6170M | Recombinant Mouse Stat3 Protein, Myc/DDK-tagged | +Inquiry |
STAT3-8786M | Recombinant Mouse STAT3 Protein, His (Fc)-Avi-tagged | +Inquiry |
STAT3-07H | Recombinant Human STAT3 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
STAT3-1418HCL | Recombinant Human STAT3 293 Cell Lysate | +Inquiry |
STAT3-1417HCL | Recombinant Human STAT3 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (7)
Ask a questionYes, there are several inhibitors targeting STAT3, including Stattic, S3I-201, and OPB-31121, which are being explored for their therapeutic potential in cancer and other diseases.
Yes, activated STAT3 can promote cell proliferation and survival by inducing the expression of genes like cyclin D1 and Bcl-xL.
STAT3 can contribute to oncogenesis by promoting cell proliferation, survival, angiogenesis, and immune evasion, and by suppressing apoptosis in various cancer types.
Activation of STAT3 can be detected using Western blotting with phospho-specific antibodies that recognize the tyrosine-phosphorylated form of STAT3.
STAT3 can interact with other signaling pathways such as the MAPK, PI3K/AKT, and NF-κB pathways, leading to integrated cellular responses.
The primary upstream activators of STAT3 are cytokines and growth factors, especially those that signal through the Janus kinase (JAK) family, such as IL-6 and EGF.
STAT3 plays a crucial role in the differentiation of Th17 cells, a subset of CD4+ T cells, and is also involved in the function of myeloid-derived suppressor cells (MDSCs) and regulatory T cells, influencing immune responses.
Customer Reviews (3)
Write a reviewProtein worked well in assay.
Fast shipping, great customer service.
Excellent purity, highly recommend.
Ask a Question for All STAT3 Products
Required fields are marked with *
My Review for All STAT3 Products
Required fields are marked with *
Inquiry Basket