Active Recombinant Human TEK protein, GST-tagged
Cat.No. : | TEK-42H |
Product Overview : | Recombinant Human TIE2 (Y897H) (771-end) fused with GST tag at N-terminal was expressed in Sf9 insect cells. |
- Specification
- Gene Information
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Description : | TIE2 or TEK is a receptor tyrosine kinase that is expressed principally on vascular endothelium. Disrupting TIE2 function in mice results in embryonic lethality with defects in embryonic vasculature, suggests a role in blood vessel maturation and maintenance. Angiopoietin-1 is a secreted growth factor that binds to and activates the TIE2 receptor tyrosine kinase. SHP2 and GRB2 are recruited to the activated TIE 2 kinase domain and are part of the cellular responses that mediate TIE2 function. TIE2 ex |
Source : | Insect cells |
Species : | Human |
Tag : | GST |
Form : | 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. |
Bio-activity : | The specific activity was determined to be 90 nmol/min/mg. |
Molecular Mass : | ~65 kDa |
Purity : | >95% by densitometry |
Applications : | Kinase Assay |
Storage : | Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Concentration : | 0.1 ug/ul |
Gene Name : | TEK TEK tyrosine kinase, endothelial [ Homo sapiens ] |
Official Symbol : | TEK |
Synonyms : | TEK; CD202b; TIE 2; TIE2; VMCM1; hTIE2; p140 TEK; VMCM; TIE-2; CD202B; |
Gene ID : | 7010 |
mRNA Refseq : | NM_000459 |
Protein Refseq : | NP_000450 |
MIM : | 600221 |
UniProt ID : | Q02763 |
Chromosome Location : | 9p21 |
Pathway : | Angiogenesis, organism-specific biosystem; Angiopoietin receptor Tie2-mediated signaling, organism-specific biosystem; Cell surface interactions at the vascular wall, organism-specific biosystem; Hemostasis, organism-specific biosystem; Rheumatoid arthritis, organism-specific biosystem; Rheumatoid arthritis, conserved biosystem; Tie2 Signaling, organism-specific biosystem; |
Function : | ATP binding; nucleotide binding; protein binding; protein kinase activity; protein tyrosine kinase activity; protein tyrosine kinase activity; receptor activity; transmembrane receptor protein tyrosine kinase activity; |
Products Types
◆ Recombinant Protein | ||
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TEK-2054H | Recombinant Human TEK Protein, Fc/His-tagged | +Inquiry |
TEK-4171H | Recombinant Human TEK Protein, His (Fc)-Avi-tagged | +Inquiry |
TEK-036H | Active Recombinant Human TEK Protein, hIgG/His-tagged | +Inquiry |
◆ Lysates | ||
TEK-1707RCL | Recombinant Rat TEK cell lysate | +Inquiry |
TEK-1511MCL | Recombinant Mouse TEK cell lysate | +Inquiry |
TEK-1065CCL | Recombinant Cynomolgus TEK cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionThe TEK gene is crucial for vascular development during embryogenesis, coordinating with other genes and signaling pathways to ensure proper formation of the vascular system.
The TEK gene is implicated in pathological angiogenesis in diseases like cancer, where dysregulation of TIE2 signaling can contribute to aberrant blood vessel formation.
The TEK gene, through TIE2 signaling, regulates vascular permeability by influencing the integrity of endothelial cell junctions and controlling the passage of molecules across blood vessels.
The TEK gene contributes to the maintenance of vascular quiescence by suppressing endothelial cell activation and inflammation, preserving the stability of blood vessels.
The TEK gene, through TIE2 signaling, influences immune responses by modulating interactions between endothelial cells and immune cells during vascular inflammation.
Customer Reviews (3)
Write a reviewOutstanding service! Staff expertise helped us choose the perfect protein.
Seamless delivery process—ordered, received, and ready for experiments.
Courteous and efficient customer service made our purchase hassle-free.
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