"TLR3" Related Products

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Recombinant Human TLR3 protein, His-tagged

Cat.No.: TLR3-25H
Product Overview: Recombinant Human TLR3(Lys27-Ser711) fused with His tag at C-terminal was expressed in NS0.
Source: NS0
Species: Human
Tag: His
Predicted N Terminal: Lys27
Form: Lyophilized from a 0.2 μm filtered solution in PBS.
Bio-activity: Measured by its ability to inhibit poly I:C induced IL-8 secretion by HEK293 human embryonic kidney cells transfected with TLR3. The ED50 for this effect is typically 5-10 µg/mL in the presence of 10 µg/mL of poly I:C.
Molecular Mass: Predicted Molecular Mass: 79.2 kDa;SDS-PAGE: 110-120 kDa, reducing conditions.
Protein length: Lys27-Ser711
Endotoxin: <0.1 EU per 1 mug of the protein by the LAL method.
Purity: >95%, by SDS-PAGE under reducing conditions and visualized by silver stain
Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.12 months from date of receipt, -20 to -70 centigrade as supplied.1 month, 2 to 8 centigrade under sterile conditions after reconstitution.3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
Reconstitution: Reconstitute at 400 μg/mL in sterile PBS.
Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Gene Name: TLR3 toll-like receptor 3 [ Homo sapiens ]
Official Symbol: TLR3
Synonyms: TLR3; toll-like receptor 3; CD283; IIAE2;
Gene ID: 7098
mRNA Refseq: NM_003265
Protein Refseq: NP_003256
MIM: 603029
UniProt ID: O15455
Chromosome Location: 4q35
Pathway: Cytosolic sensors of pathogen-associated DNA, organism-specific biosystem; DAI mediated induction of type I IFNs, organism-specific biosystem; Hepatitis C, organism-specific biosystem; Hepatitis C, conserved biosystem; Herpes simplex infection, organism-specific biosystem; Herpes simplex infection, conserved biosystem; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation, organism-specific biosystem;
Function: double-stranded RNA binding; double-stranded RNA binding; receptor activity; transmembrane signaling receptor activity;

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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