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Recombinant Human TMPRSS2 protein, His-tagged

Cat.No. : TMPRSS2-4899H
Product Overview : Recombinant Human TMPRSS2(106-492 aa) fused with His tag was expressed in HEK293.
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  • Gene Information
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Description : This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Source : HEK293
Species : Human
Tag : His
Form : Tris-based buffer,50% glycerol
Protein length : 106-492 aa
AA Sequence : WKFMG SKCSNSGIEC DSSGTCINPS NWCDGVSHCP GGEDENRCVR LYGPNFILQV YSSQRKSWHP VCQDDWNENY GRAACRDMGY KNNFYSSQGI VDDSGSTSFM KLNTSAGNVD IYKKLYHSDA CSSKAVVSLR CIACGVNLNS SRQSRIVGGE SALPGAWPWQ VSLHVQNVHV CGGSIITPEW IVTAAHCVEK PLNNPWHWTA FAGILRQSFM FYGAGYQVEK VISHPNYDSK TKNNDIALMK LQKPLTFNDL VKPVCLPNPG MMLQPEQLCW ISGWGATEEK GKTSEVLNAA KVLLIETQRC NSRYVYDNLI TPAMICAGFL QGNVDSCQGD SGGPLVTSKN NIWWLIGDTS WGSGCAKAYR PGVYGNVMVF TDWIYRQMRA DG
Purity : >90% ( SDS-PAGE )
Notes : Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
Storage : Store at -20 centigrade, for extended storage, conserve at -20 centigrade or -80 centigrade.
Gene Name : TMPRSS2 transmembrane protease, serine 2 [ Homo sapiens ]
Official Symbol : TMPRSS2
Synonyms : TMPRSS2; transmembrane protease, serine 2; transmembrane protease serine 2; PRSS10; epitheliasin; serine protease 10; PP9284; FLJ41954;
Gene ID : 7113
mRNA Refseq : NM_001135099
Protein Refseq : NP_001128571
MIM : 602060
UniProt ID : O15393
Chromosome Location : 21q22.3
Pathway : Coregulation of Androgen receptor activity, organism-specific biosystem; Influenza A, organism-specific biosystem; Influenza A, conserved biosystem; Regulation of Androgen receptor activity, organism-specific biosystem; Transcriptional misregulation in cancer, organism-specific biosystem; Transcriptional misregulation in cancer, conserved biosystem;
Function : peptidase activity; scavenger receptor activity; serine-type endopeptidase activity; serine-type peptidase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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Are there regulators related to the regulation of TMPRSS2 protein expression? 12/09/2019

Yes, transcription factors and signaling pathways have been identified that are associated with the regulation of the expression of TMPRSS2 proteins, which regulate the expression levels and activity of TMPRSS2 proteins.

What is the use of TMPRSS2 protein in laboratory diagnostics? 08/19/2019

TMPRSS2 protein can be used to aid the diagnosis of certain tumors. Measuring the expression level of TMPRSS2 proteins in tumor tissues can be used as an auxiliary marker to determine disease type and prognosis.

What is the role of TMPRSS2 protein in viral infection? 08/06/2019

TMPRSS2 proteins play an important role in some viral infections. For example, in novel coronavirus (SARS-CoV-2) infection, TMPRSS2 proteins facilitate the entry of the virus into host cells.

Are there proteins that interact with TMPRSS2 proteins? 05/08/2019

Yes, proteins that interact with TMPRSS2 proteins have been discovered, including viral proteins, cell surface receptors, etc. These interactions are involved in biological processes such as viral invasion and cell signaling.

What is the current research progress on TMPRSS2 proteins? 05/01/2019

Research on TMPRSS2 protein is going on. At present, it mainly focuses on the analysis of its function, the identification of gene mutations associated with diseases, and the interaction with other proteins, providing a theoretical basis for further understanding of diseases related to TMPRSS2 proteins.

Is the expression level of TMPRSS2 protein in lung cancer related to prognosis? 04/19/2019

Some studies have shown that high expression of TMPRSS2 protein in lung cancer may be associated with a poorer prognosis. However, the specific mechanisms need to be further studied to confirm.

Customer Reviews (3)

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Reviews
02/04/2021

    Stable and did not change significantly during storage and transportation.

    04/25/2020

      High solubility makes it easy to prepare the desired concentration.

      05/13/2019

        The protein had good crystallinity, which was beneficial for crystallographic study.

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