Recombinant Human TNC(1888-2201 aa) fused with His tag was expressed in E. coli.
Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6.
DSPRDLTATE VQSETALLTW RPPRASVTGY LLVYESVDGT VKEVIVGPDT TSYSLADLSP STHYTAKIQA LNGPLRSNMI QTIFTTIGLL YPFPKDCSQA MLNGDTTSGL YTIYLNGDKA EALEVFCDMT SDGGGWIVFL RRKNGRENFY QNWKAYAAGF GDRREEFWLG LDNLNKITAQ GQYELRVDLR DHGETAFAVY DKFSVGDAKT RYKLKVEGYS GTAGDSMAYH NGRSFSTFDK DTDSAITNCA LSYKG
Greater than 90% as determined by SDS-PAGE.
Store at -20 centigrade, for extended storage, conserve at -20 centigrade or -80 centigrade.