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Recombinant Mouse Wnt5a Protein, Gln38-Lys380

Cat.No. : WNT5A-19H
Product Overview : Recombinant human/Mouse Wnt5a protein (Gln38-Lys380) without tag was expressed in Chinese Hamster Ovary cell line.
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Description : Enables frizzled binding activity; protein domain specific binding activity; and receptor ligand activity. Involved in several processes, including Wnt signaling pathway; heart development; and positive regulation of macromolecule metabolic process. Acts upstream of or within several processes, including animal organ development; positive regulation of protein phosphorylation; and regulation of animal organ morphogenesis. Located in cell surface and extracellular matrix. Is expressed in several structures, including alimentary system; embryo ectoderm; genitourinary system; limb; and sensory organ. Used to study Robinow syndrome. Human ortholog(s) of this gene implicated in autosomal dominant Robinow syndrome 1. Orthologous to human WNT5A (Wnt family member 5A).
Source : CHO
Species : Mouse
Protein length : Gln38-Lys380
Bio-activity : Measured by its ability to inhibit Wnt-3a-induced alkaline phosphatase production by MC3T3-E1 mouse preosteoblast cells. The ED50 for this effect is 0.1-0.5 μg/mL, in the presence of 5 ng/mL rmWnt-3a. Optimal concentrations should be determined by each laboratory for each application.
Molecular Mass : Predicted Molecular Mass: 38 kDa
SDS-PAGE: 45 kDa, reducing conditions
Endotoxin : < 1 EU/μg by LAL
Purity : > 80%, by SDS-PAGE under reducing conditions and visualized by silver stain.
N-terminal Sequence Analysis : Asn44 & No results obtained: Gln38 predicted
Storage : Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 centigrade as supplied.
1 month, 2 to 8 centigrade under sterile conditions after reconstitution.
3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
Storage Buffer : Lyophilized from a 0.2 μm filtered solution in PBS, EDTA and CHAPS with BSA as a carrier protein.
Reconstitution : Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.
Gene Name : Wnt5a wingless-type MMTV integration site family, member 5A [ Mus musculus (house mouse) ]
Official Symbol : Wnt5a
Synonyms : Wnt5a; wingless-type MMTV integration site family, member 5A; Wnt-5a; 8030457G12Rik; protein Wnt-5a; wingless-related MMTV integration site 5A
Gene ID : 22418
mRNA Refseq : NM_009524
Protein Refseq : NP_033550
UniProt ID : P22725

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What role does WNT5A play in cancer biology? 09/05/2022

Its role in cancer is complex, acting as a tumor suppressor or promoter depending on context.

How does WNT5A interact with its receptors to initiate signal transduction? 04/24/2022

It binds to Frizzled receptors and co-receptors, activating non-canonical Wnt signaling pathways.

In which developmental processes is WNT5A critically involved? 03/14/2022

WNT5A is involved in embryonic development, particularly in limb formation and organogenesis.

How is WNT5A implicated in immune system regulation? 01/03/2022

WNT5A modulates various immune responses, influencing inflammation and cell migration.

What is the primary role of WNT5A in cellular processes? 10/29/2020

WNT5A is crucial in regulating cell proliferation, migration, and differentiation.

What therapeutic strategies are being explored involving WNT5A modulation? 11/14/2019

Strategies include developing WNT5A modulators for potential use in cancer therapy and regenerative medicine.

Are there known genetic mutations in WNT5A associated with specific diseases? 02/27/2019

Genetic mutations and altered expression of WNT5A are linked to developmental disorders and cancer.

Customer Reviews (3)

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Reviews
11/14/2019

    Satisfied with performance, quality.

    08/27/2019

      Great product, satisfied customer.

      02/27/2019

        High purity, works well.

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