Recombinant Human YAP1 protein, MYC/DDK-tagged
Cat.No. : | YAP1-19H |
Product Overview : | Recombinant Human YAP1, transcript variant 1, fused with MYC/DDK tag at C-terminal was expressed in HEK293. |
- Specification
- Gene Information
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Description : | This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis. This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment. Alternative splicing results in multiple transcript variants encoding different isoforms. |
Source : | HEK293 |
Species : | Human |
Tag : | MYC/DDK |
Form : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Molecular Mass : | 54.3 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Concentration : | >50 ug/mL as determined by microplate BCA method |
Gene Name : | YAP1 Yes-associated protein 1 [ Homo sapiens ] |
Official Symbol : | YAP1 |
Synonyms : | YAP1; Yes-associated protein 1; Yes associated protein 1, 65kDa; yorkie homolog; YAP65; yes-associated protein 2; yes-associated protein beta; yes-associated protein delta; 65 kDa Yes-associated protein; YAP; YKI; YAP2; |
Gene ID : | 10413 |
mRNA Refseq : | NM_001130145 |
Protein Refseq : | NP_001123617 |
MIM : | 606608 |
UniProt ID : | P46937 |
Chromosome Location : | 11q13 |
Pathway : | ErbB4 signaling events, organism-specific biosystem; Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem; Gene ex |
Function : | protein binding; transcription coactivator activity; transcription corepressor activity; transcription regulatory region DNA binding; |
Products Types
◆ Recombinant Protein | ||
YAP1-10247M | Recombinant Mouse YAP1 Protein, His (Fc)-Avi-tagged | +Inquiry |
YAP1-600H | Recombinant Human YAP1 Protein, His-tagged | +Inquiry |
YAP1-6278R | Recombinant Rat YAP1 Protein, His (Fc)-Avi-tagged | +Inquiry |
YAP1-1556H | Recombinant Human YAP1 Protein (1-504 aa), His-tagged | +Inquiry |
Yap1-7027M | Recombinant Mouse Yap1 Protein, Myc/DDK-tagged | +Inquiry |
◆ Lysates | ||
YAP1-250HCL | Recombinant Human YAP1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionThe research and development directions of antitumor drugs of YAP1 protein include inhibitors targeting YAP1, drugs that regulate the downstream signaling pathway of YAP1, and combination drug strategies.
YAP1 protein is regulated in multiple signaling pathways such as Wnt/β-catenin, Hippo, and FGF, thereby affecting cell proliferation and growth.
YAP1 protein plays a key role in the HIPPO signaling pathway, and its activation or inactivation affects cell proliferation, apoptosis, and differentiation.
YAP1 protein participates in tumor invasion and metastasis by regulating epithelial-mesenchymal transformation, cell migration and the expression of invasion-related factors.
The YAP1 protein is involved in regulating cell proliferation and growth, mainly through nuclear translocation and interaction with nuclear transcription factors to regulate the expression of related genes.
Post-translational modifications of YAP1 protein, such as phosphorylation and acetylation, can regulate its transcriptional activity and subcellular localization, thereby affecting tumor development.
Customer Reviews (3)
Write a reviewThis short half-life and high clearance of YAP1 allow it to penetrate the tissue and reach the lesion site, which improves the therapeutic effect.
The green production process of YAP1 not only improves the production efficiency, but also minimizes the environmental impact, truly realizing a win-win situation of economic and environmental benefits.
The potent biological activity of YAP1 combined with its high purity makes the experimental results highly reliable.
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