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Recombinant Human YAP1 protein, MYC/DDK-tagged

Cat.No. : YAP1-19H
Product Overview : Recombinant Human YAP1, transcript variant 1, fused with MYC/DDK tag at C-terminal was expressed in HEK293.
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Description : This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis. This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment. Alternative splicing results in multiple transcript variants encoding different isoforms.
Source : HEK293
Species : Human
Tag : MYC/DDK
Form : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass : 54.3 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : YAP1 Yes-associated protein 1 [ Homo sapiens ]
Official Symbol : YAP1
Synonyms : YAP1; Yes-associated protein 1; Yes associated protein 1, 65kDa; yorkie homolog; YAP65; yes-associated protein 2; yes-associated protein beta; yes-associated protein delta; 65 kDa Yes-associated protein; YAP; YKI; YAP2;
Gene ID : 10413
mRNA Refseq : NM_001130145
Protein Refseq : NP_001123617
MIM : 606608
UniProt ID : P46937
Chromosome Location : 11q13
Pathway : ErbB4 signaling events, organism-specific biosystem; Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem; Gene expression, organism-specific biosystem; Generic Transcription Pathway, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of lipids and lipoproteins, organism-specific biosystem; Nuclear signaling by ERBB4, organism-specific biosystem;
Function : protein binding; transcription coactivator activity; transcription corepressor activity; transcription regulatory region DNA binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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What are the research and development directions of anti-tumor drugs for YAP1 protein? 07/17/2022

The research and development directions of antitumor drugs of YAP1 protein include inhibitors targeting YAP1, drugs that regulate the downstream signaling pathway of YAP1, and combination drug strategies.

In which signaling pathways are YAP1 proteins regulated? 07/13/2022

YAP1 protein is regulated in multiple signaling pathways such as Wnt/β-catenin, Hippo, and FGF, thereby affecting cell proliferation and growth.

What signaling pathways does the YAP1 protein play a key role? 11/12/2021

YAP1 protein plays a key role in the HIPPO signaling pathway, and its activation or inactivation affects cell proliferation, apoptosis, and differentiation.

How does the YAP1 protein participate in tumor invasion and metastasis? 02/27/2021

YAP1 protein participates in tumor invasion and metastasis by regulating epithelial-mesenchymal transformation, cell migration and the expression of invasion-related factors.

How is YAP1 protein involved in the regulation of cell proliferation and growth? 01/19/2021

The YAP1 protein is involved in regulating cell proliferation and growth, mainly through nuclear translocation and interaction with nuclear transcription factors to regulate the expression of related genes.

What are the effects of post-translational modifications of the YAP1 protein? 12/02/2020

Post-translational modifications of YAP1 protein, such as phosphorylation and acetylation, can regulate its transcriptional activity and subcellular localization, thereby affecting tumor development.

Customer Reviews (3)

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Reviews
11/19/2022

    This short half-life and high clearance of YAP1 allow it to penetrate the tissue and reach the lesion site, which improves the therapeutic effect.

    09/23/2022

      The green production process of YAP1 not only improves the production efficiency, but also minimizes the environmental impact, truly realizing a win-win situation of economic and environmental benefits.

      10/13/2019

        The potent biological activity of YAP1 combined with its high purity makes the experimental results highly reliable.

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