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Recombinant Mouse Adamts7 protein, His-tagged

Cat.No. : Adamts7-512M
Product Overview : Recombinant Mouse Adamts7(Lys226~Pro437) fused with His tag at N-terminal was expressed in E. coli.
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Description : This gene encodes a member of "a disintegrin and metalloproteinase with thrombospondin motifs" (ADAMTS) family of multi-domain matrix-associated metalloendopeptidases that have diverse roles in tissue morphogenesis and pathophysiological remodeling, in inflammation and in vascular biology. The encoded preproprotein undergoes proteolytic processing to generate an active, zinc-dependent enzyme that degrades cartilage oligomeric matrix protein. The deficiency of the encoded protein decreases atherosclerosis in genetically hyperlipidemic mice and in response to vascular injury. Alternative splicing results in multiple transcript variants encoding different isoforms, some of which may undergo similar processing.
Source : E. coli
Species : Mouse
Tag : His
Form : Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl.
Molecular Mass : 25.2 kDa
AA Sequence : KWVET LVVADSKMVE YHGQPQVESY VLTIMNMVAG LFHDPSIGNP IHISIVRLII LEDEEKDLKI THHAEETLKN FCRWQKNINI KGDDHPQHHD TAILLTRKDL CASMNQPCET LGLSHVSGLC HPQLSCSVSE DTGMPLAFTV AHELGHSFGI QHDGTGNDCE SIGKRPFIMS PQLLYDRGIP LTWSRCSREY ITRFLDRGWG LCLDDRP
Endotoxin : <1.0EU per 1µg (determined by the LAL method)
Purity : > 90%
Applications : SDS-PAGE; WB; ELISA; IP.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
Reconstitution : Reconstitute in sterile PBS, pH7.2-pH7.4.
Gene Name : Adamts7 a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 7 [ Mus musculus ]
Official Symbol : Adamts7
Synonyms : ADAMTS7; a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 7; A disintegrin and metalloproteinase with thrombospondin motifs 7; COMPase; ADAMTS-7; ADAM-TS 7; metalloprotease; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 7; ADAM-TS7; ADAMTS7B;
Gene ID : 108153
mRNA Refseq : NM_001003911
Protein Refseq : NP_001003911
Chromosome Location : 9; 9 E3.1
Function : hydrolase activity; metal ion binding; metalloendopeptidase activity; metallopeptidase activity; peptidase activity; zinc ion binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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In addition to research related to atherosclerosis, what other diseases is ADAMTS7 currently being used to study? 01/25/2022

ADAMTS7 is also currently used in the study of diseases such as hepatocellular carcinoma and oral cancer.

How is ADAMTS7 related to TSP1? 01/14/2022

ADAMTS7 can cleave TSP1.

What are the biological functions of ADAMTS7? 09/11/2021

ADAMTS7 is involved in mediating endothelial proliferation and vascular smooth muscle cell migration after arterial balloon injury. It also promotes degradation of thrombin-sensitive protein-1, inhibits reendothelialization of injured arteries, and promotes vascular remodeling.

Which protein does ADAMTS7 share the highest homology with? 07/09/2020

ADAMTS7 has the highest homology with ADAMTS12.

ADAMTS7 is strongly associated with the development of which diseases? 05/14/2020

ADAMTS7 is strongly associated with atherosclerosis, acute myocardial infarction and ischemia/reperfusion injury.

Customer Reviews (3)

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Reviews
08/12/2022

    Customer service contacted me in a timely manner and helped me solve a lot of problems that arose in my experiments.

    11/23/2020

      The product was kept in perfect condition and delivered on time so that I got the perfect product in the shortest time possible.

      10/19/2020

        The after-sales service of the product is guaranteed, which has helped me solve many problems in the experiment.

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