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Recombinant Mouse Cd36 Protein, His-tagged

Cat.No. : Cd36-365M
Product Overview : Recombinant mouse CD36, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
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Description : CD36, also known as platelet glycoprotein 4, is an integral membrane glycoprotein that has multiple physiological functions. It is broadly expressed on a variety of cell types. As a member of the scavenger receptor family, CD36 is a multiligand pattern recognition receptor that interacts with a large number of structurally dissimilar ligands. It plays a role in lipid metabolism and has been identified as a fatty acid translocase necessary for the binding and transport of LCFA in cells and tissues. It also plays a significant role in the initiation and pathogenesis of chronic inflammatory diseases such as Alzheimer"s disease and atherosclerosis. It is an integral membrane protein primarily serving as receptors for thrombospondin and collagen and by the erythrocytes infected with the human malaria parasite.
Source : Insect cell
Species : Mouse
Tag : His
Form : Liquid. In Phosphate Buffered Saline (pH 7.4) containing 10% glycerol.
Molecular Mass : 47.4kDa (419aa)57-70kDa (SDS-PAGE under reducing conditions)
AA Sequence : ADPGDMLIEK TIKREVVLEE GTTAFKNWVK TGTTVYRQFW IFDVQNPDDV AKNSSKIKVK QRGPYTYRVR YLAKENITQD PEDHTVSFVQPNGAIFEPSL SVGTEDDNFT VLNLAVAAAP HIYQNSFVQV VLNSLIKKSK SSMFQTRSLK ELLWGYKDPF LSLVPYPIST TVGVFYPYNDTVDGVYKVFN GKDNISKVAI IESYKGKRNL SYWPSYCDMI NGTDAASFPP FVEKSRTLRF FSSDICRSIY AVFGSEIDLK GIPVYRFVLPANAFASPLQN PDNHCFCTEK VISNNCTSYG VLDIGKCKEG KPVYISLPHF LHASPDVSEP IEGLHPNEDE HRTYLDVEPI TGFTLQFAKRLQVNILVKPA RKIEALKNLK RPYIVPILWL NETGTIGDEK AEMFKTQVTG KIKHHHHHH
Endotoxin : < 1.0 EU per 1 microgram of protein (determined by LAL method)
Purity : >95% by SDS - PAGE
Storage : Can be stored at +4 centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20 centigrade or -70 centigrade. Avoid repeated freezing and thawing cycles.
Concentration : 1mg/ml (determined by Absorbance at 280nm)
Gene Name : Cd36 CD36 antigen [ Mus musculus ]
Official Symbol : Cd36
Synonyms : CD36; CD36 antigen; platelet glycoprotein 4; PAS-4; GPIIIB; PAS IV; glycoprotein IIIb; fatty acid translocase; platelet glycoprotein IV; FAT; GPIV; Scarb3;
Gene ID : 12491
mRNA Refseq : NM_001159555
Protein Refseq : NP_001153027
MIM :
UniProt ID :
Pathway : Adipocytokine signaling pathway, organism-specific biosystem; Adipocytokine signaling pathway, conserved biosystem; ECM-receptor interaction, organism-specific biosystem; ECM-receptor interaction, conserved biosystem; Fat digestion and absorption, organism-specific biosystem; Fat digestion and absorption, conserved biosystem; Hematopoietic cell lineage, organism-specific biosystem;
Function : Gram-negative bacterial cell surface binding; Gram-positive bacterial cell surface binding; high-density lipoprotein particle binding; lipid binding; lipid binding; lipoprotein particle binding; lipoteichoic acid receptor activity; low-density lipoprotein particle binding; low-density lipoprotein particle binding; low-density lipoprotein receptor activity; low-density lipoprotein receptor activity; receptor activity; thrombospondin receptor activity; transforming growth factor beta binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What is the impact of CD36 on inflammation and the immune response, particularly in chronic inflammatory diseases? 01/23/2022

CD36 is involved in inflammation and immune responses, potentially exacerbating chronic inflammatory conditions.

How do alterations in CD36 expression or activity affect obesity and related health complications? 07/08/2021

Variations in CD36 function can influence the risk of obesity and associated health issues like metabolic syndrome.

What are the mechanisms by which CD36 modulates cell signaling and energy homeostasis? 03/15/2021

CD36 modulates cell signaling related to energy utilization and storage, impacting metabolic health.

How does CD36 contribute to the pathogenesis of metabolic disorders, such as insulin resistance and type 2 diabetes? 03/01/2021

CD36 affects the development of metabolic disorders by influencing lipid metabolism and insulin sensitivity.

How does CD36 influence taste perception, especially in the detection of dietary fats? 06/27/2020

CD36 aids in taste perception, particularly in detecting and responding to dietary fats.

What role does CD36 play in the development of cardiovascular diseases like atherosclerosis? 02/09/2020

CD36 is implicated in cardiovascular diseases, contributing to the formation of atherosclerotic plaques.

How does CD36 (Cluster of Differentiation 36) function in fatty acid metabolism and uptake? 08/27/2019

CD36 facilitates the uptake and metabolism of fatty acids in cells, playing a critical role in lipid processing.

Customer Reviews (3)

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Reviews
05/21/2020

    Dependable protein purification, consistently high-quality results.

    04/10/2019

      Great antibody validation, enhances our immunoprecipitation experiments.

      12/28/2018

        Swift protein expression optimization, invaluable for our research efficiency.

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