Active Recombinant Mouse EGFR Protein, His-tagged
Cat.No. : | EGFR-100M |
Product Overview : | Recombinant Mouse EGFR Protein extracellular domain 25-618aa (signal peptide removed), fused with a C-terminal His tag, was expressed in HEK293. |
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- Gene Information
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Description : | As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently. |
Source : | HEK293 |
Species : | Mouse |
Tag : | His |
Predicted N Terminal : | Leu 22 |
Form : | Lyophilized from sterile PBS, pH 7.4. |
Bio-activity : | Measured by its binding ability in a functional ELISA. |
Molecular Mass : | The recombinant mature mouse EGFR protein consists of 600 amino acids and has a calculated molecular mass of 67.2 KD. |
Endotoxin : | <1.0EU/ug, LAL method |
Purity : | >95% (SDS-PAGE) |
Stability : | Samples are stable for up to twelve months from date of receipt at -70ºC. |
Storage : | Store it under sterile conditions at -20ºC~-70ºC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents. |
Gene Name : | Egfr epidermal growth factor receptor [ Mus musculus ] |
Official Symbol : | EGFR |
Synonyms : | EGFR; epidermal growth factor receptor; waved 2; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog; Wa5; wa2; Erbb; Errp; wa-2; AI552599; 9030024J15Rik; |
Gene ID : | 13649 |
mRNA Refseq : | NM_007912 |
Protein Refseq : | NP_031938 |
Pathway : | Adherens junction, organism-specific biosystem; Adherens junction, conserved biosystem; Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem; Androgen Receptor Signaling Pathway, organism-specific biosystem; Axon guidance, organism-specific biosystem; Bladder cancer, organism-specific biosystem; Bladder cancer, conserved biosystem; |
Function : | ATP binding; actin filament binding; enzyme binding; epidermal growth factor binding; epidermal growth factor-activated receptor activity; epidermal growth factor-activated receptor activity; glycoprotein binding; identical protein binding; integrin binding; kinase activity; nucleotide binding; protein binding; protein heterodimerization activity; protein kinase activity; protein kinase binding; protein phosphatase binding; protein tyrosine kinase activity; receptor activity; receptor binding; receptor signaling protein tyrosine kinase activity; signal transducer activity; transferase activity; transferase activity, transferring phosphorus-containing groups; transmembrane receptor protein tyrosine kinase activity; transmembrane signaling receptor activity; |
Products Types
◆ Recombinant Protein | ||
EGFR-1228R | Active Recombinant Rhesus EGFR protein(Met1-Ser645), His-tagged | +Inquiry |
EGFR-3383C | Active Recombinant Cynomolgus EGFR protein(Met1-Ser645), His-tagged | +Inquiry |
EGFR-212H | Recombinant Human EGFR Protein, Fc-tagged | +Inquiry |
EGFR-143E | Recombinant Human EGFR Protein (627 aa), His-tagged | +Inquiry |
EGFR-214M | Recombinant Mouse EGFR Protein, His-tagged | +Inquiry |
◆ Lysates | ||
EGFR-2733HCL | Recombinant Human EGFR cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionIt is associated with biological processes in human embryonic development and tissue regeneration.
EGFR inhibits adverse drug reactions such as rash, inflammation, and diarrhea during drug treatment.
The role of EGFR in tumor treatment is to act as a molecular marker and can be used as a prognostic indicator and monitor tumor progression; at the same time, EGFR mutations can also be targeted for targeted therapy.
EGFR gene mutation detection generally uses PCR, fluorescence in situ hybridization, and direct sequencing.
The combination of EGFR inhibitors with chemotherapy drugs, radiotherapy, immunotherapy, etc. can increase the efficacy of treatment and reduce the occurrence of adverse reactions.
EGFR mutations can have a significant impact on the efficacy of targeted therapies, and patients with mutations have higher response rates.
Customer Reviews (3)
Write a reviewThe powerful biological activity of EGFR combined with its high purity makes the experimental results highly reproducible, which is of great significance in the field of scientific research.
Due to the short half-life and high clearance characteristics of EGFR, they can better adapt to the needs of clinical treatment and provide more treatment options for patients.
The production process of EGFR uses advanced biotechnology, which makes the production process more efficient and environmentally friendly, and reduces the consumption of human and material resources.
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