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Recombinant Mouse Flt3l protein, His-tagged

Cat.No. : Flt3l-457M
Product Overview : Recombinant Mouse Flt3l (Gly27-Arg188) protein was fused to His-tag at C-terminus and expressed in human 293 cells (HEK293).
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Description : FMS-like tyrosine kinase 3 ligand (Flt-3 Ligand) is also known as FL, Flt3L and FLT3LG, is an α-helical cytokine that promotes the differentiation of multiple hematopoietic cell lineages. FLT3LG is expressed as a noncovalentlylinked dimer by T cells and bone marrow and thymic fibroblasts. Each 36 kDa chain carries approximately 12 kDa of N- and O- linked carbohydrates. FLT3LG is structurally homologous to stem cell factor (SCF) and colony stimulating facor 1 (CSF-1). FLT3LG acts as a growth factor that increases the number of immune cells by activating the hematopoietic progenitors. It also induces the mobilization of the hematopoietic progenitors and stem cells in vivo which may help the system to kill cancer cells. FLT3LG induces the expansion of monocytes and immature dendritic cells as well as early B cell lineage differentiation. FLT3LG cooperates with IL2, IL6, IL7, and IL15 to induce NK cell development and with IL3, IL7 and IL11 to induce terminal B cell maturation. Animal studies also show FLT3LG to reduce the severity of experimentally induced allergic inflammation. FLT3LG is crucial for steady-state pDC and cDC development. A lack of FLT3L results in low levels of DCs.
Source : HEK293
Species : Mouse
Tag : His
Predicted N Terminal : Gly27
Form : Lyophilized from 0.22 μm filtered solution in PBS, pH7.4, 10% trehalose.
Molecular Mass : The protein has a calculated MW of 20.2 kDa. The protein migrates as 25-33 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Protein length : Gly27-Arg188
Endotoxin : Less than 1.0 EU per μg by the LAL method.
Purity : >90% as determined by SDS-PAGE.
Storage : For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20 to -70 centigrade for 12 months in lyophilized state;
-70 centigrade for 3 months under sterile conditions after reconstitution.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.
Gene Name : Flt3l
Official Symbol : Flt3l
Synonyms : Flt3lg, Ly72L
Gene ID : 14256
mRNA Refseq : NM_013520.3
Protein Refseq : NP_038548.3
UniProt ID : P49772

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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In what ways does FLT3L impact the differentiation of hematopoietic progenitor cells? 02/21/2023

FLT3L promotes the differentiation of hematopoietic progenitor cells into various blood cell lineages, contributing to the diversity of blood cell types.

Are there any side effects associated with FLT3L-based therapies? 10/07/2022

Common side effects may include flu-like symptoms, fatigue, and gastrointestinal disturbances, but the severity varies among individuals.

How does FLT3L influence dendritic cell development and function? 06/13/2022

FLT3L is a crucial factor in the development and maturation of dendritic cells, playing a role in immune response regulation.

How does FLT3L contribute to the maintenance of hematopoietic stem cells in the bone marrow? 06/30/2021

FLT3L supports the maintenance and self-renewal of hematopoietic stem cells in the bone marrow, influencing the overall balance of blood cell production.

Can FLT3L be used as a prognostic marker in leukemia patients? 05/22/2017

Yes, elevated FLT3L levels can serve as a prognostic marker, helping to predict the likelihood of relapse and overall survival in leukemia patients.

Customer Reviews (3)

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Reviews
01/23/2023

    I am confident in the manufacturer's ability to deliver outstanding technical support.

    04/04/2021

      By incorporating the FLT3L protein into my experiments, I am confident that I am utilizing a product that meets the highest standards of quality and performance.

      08/28/2018

        Its high purity and integrity provide the necessary assurance for consistent and reliable results, enabling me to achieve precise and meaningful outcomes in my research.

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