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Recombinant Mouse Hao1 protein, His/GST-tagged

Cat.No. : Hao1-840M
Product Overview : Recombinant Mouse Hao1(Ser113~Lys369) fused with His/GST tag at N-terminal was expressed in E. coli.
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Source : E. coli
Species : Mouse
Tag : His/GST
Form : Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl.
Molecular Mass : 60.5 kDa
Protein length : Ser113~Lys369
AA Sequence : MSPILGYWKIKGLVQPTRLLLEYLE EKYEEHLYERDEGDKWRNKKFELGL EFPNLPYYIDGDVKLTQSMAIIRYI ADKHNMLGGCPKERAEISMLEGAVL DIRYGVSRIAYSKDFETLKVDFLSK LPEMLKMFEDRLCHKTYLNGDHVTH PDFMLYDALDVVLYMDPMCLDAFPK LVCFKKRIEAIPQIDKYLKSSKYIA WPLQGWQATFGGGDHPPKSDGSTSG SGHHHHHHSAGLVPRGSTAIGMKET AAAKFERQHMDSPDLGTGGGSGIEG RGSMGYRGS-SSIEEVAE AGPEALRWMQ LYIYKDREIS RQIVKRAEKQ GYKAIFVTVD TPYLGNRIDD VRNRFKLPPQ LRMKNFETND LAFSPKGNFG DNSGLAEYVA QAIDPSLSWD DITWLRRLTS LPIVVKGILR GDDAKEAVKH GVDGILVSNH GARQLDGVPA TIDVLPEIVE AVEGKVEVFL DGGVRKGTDV LKALALGAKA VFVGRPIIWG LAFQGEKGVQ DVLEILKEEF RLAMALSGCQ NVKVIDKTLV RKNPLAVSK
Endotoxin : <1.0eu per 1µg (determined by the lal>
Purity : >95%
Applications : SDS-PAGE; WB; ELISA; IP.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8oC for one month. Aliquot and store at -80oC for 12 months.
Reconstitution : Reconstitute in sterile PBS, pH7.2-pH7.4.
Gene Name : Hao1 hydroxyacid oxidase 1, liver [ Mus musculus ]
Official Symbol : Hao1
Synonyms : HAO1; hydroxyacid oxidase 1, liver; hydroxyacid oxidase 1; HAOX1; glycolate oxidase 1; GOX; Gox1; Hao-1; MGC141211;
Gene ID : 15112
mRNA Refseq : NM_010403
Protein Refseq : NP_034533
MIM :
UniProt ID : Q9WU19
Chromosome Location : 2 F2; 2 65.65 cM
Pathway : Glyoxylate and dicarboxylate metabolism, organism-specific biosystem; Glyoxylate and dicarboxylate metabolism, conserved biosystem; Glyoxylate metabolism, organism-specific biosystem; Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of amino acids and derivatives, organism-specific biosystem; Peroxisome, organism-specific biosystem;
Function : (S)-2-hydroxy-acid oxidase activity; (S)-2-hydroxy-acid oxidase activity; FMN binding; catalytic activity; glycolate oxidase activity; long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity; medium-chain-(S)-2-hydroxy-acid oxidase activity; oxidoreductase activity; very-long-chain-(S)-2-hydroxy-acid oxidase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How is HAO1 implicated in metabolic disorders? 02/14/2022

Dysregulation of HAO1 is linked to metabolic disorders and fatty liver disease.

Are there existing or potential therapeutic strategies targeting HAO1? 09/04/2021

Therapeutic approaches may include modulation of HAO1 activity or expression.

How does HAO1 contribute to fatty acid metabolism? 08/15/2020

It oxidizes specific fatty acids, contributing to their breakdown.

What are the key biological functions of HAO1? 07/14/2020

HAO1 is involved in peroxisomal fatty acid oxidation, crucial for lipid metabolism.

What are the potential consequences of HAO1 overexpression? 06/15/2020

HAO1 overexpression may lead to oxidative stress and liver dysfunction.

What role does HAO1 play in liver function? 01/01/2019

HAO1 supports liver function by participating in lipid catabolism.

How is HAO1 activity regulated in cells? 10/13/2018

Cellular regulation of HAO1 involves transcriptional and post-translational mechanisms.

Customer Reviews (3)

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Reviews
05/09/2022

    Worked well in experiments.

    11/28/2020

      Great for academic research.

      01/28/2020

        Very satisfied, will buy again.

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