Active Recombinant Mouse Idua protein, His-tagged
Cat.No. : | Idua-220M |
Product Overview : | Recombinant Mouse Idua (Glu17-Ser634) fused with His tag at C-terminal was expressed in NS0. |
- Specification
- Gene Information
- Related Products
Description : | alpha -L-Iduronidase encoded by the IDUA gene is an important enzyme required for the lysosomal degradation of glycosaminoglycans (GAGS). It hydrolyzes the non-reducing terminal alpha -L-iduronic acid residues in GAGS including dermatan sulfate and heparan sulfate. Mature mouse IDUA shares 80% aa identity with human IDUA. Mutations in IDUA that result in enzymatic deficiency lead to the autosomal recessive disease mucopolysaccharidosis type I (MPS I). MPS I can be classified as three clinical subtypes; Hurler syndrome, Hurler-Scheie syndrome, and Scheie syndrome with decreasing severity, respectively. MPS I causes progressive cellular, tissue and organ damage, and several clinical studies using enzyme replacement therapy show positive results. Recently, the IDUA gene has been linked to osteoporosis. |
Source : | Mammalian cells |
Species : | Mouse |
Tag : | His |
Predicted N Terminal : | Glu17 |
Form : | Supplied as a 0.2 μm filtered solution in Sodium Acetate, NaCl and Glycerol. |
Bio-activity : | Measured by its ability to cleave a fluorogenic substrate, 4-Methylumbelliferyl alpha -L-iduronide. The specific activity is >7,500 pmol/min/ug. |
Molecular Mass : | Predicted Molecular Mass: 70 kDa SDS-PAGE: 83-95 kDa, reducing conditions |
Endotoxin : | <0.1 EU per 1 μg of the protein by the LAL method. |
Purity : | >95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining. |
Storage : | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 centigrade as supplied. 3 months, -20 to -70 centigrade under sterile conditions after opening. |
Gene Name : | Idua iduronidase, alpha-L- [ Mus musculus ] |
Official Symbol : | Idua |
Synonyms : | IDUA; iduronidase, alpha-L-; alpha-L-iduronidase; 6030426D08; |
Gene ID : | 15932 |
mRNA Refseq : | NM_008325 |
Protein Refseq : | NP_032351 |
Products Types
◆ Recombinant Protein | ||
IDUA-1140H | Recombinant Human IDUA Protein, His (Fc)-Avi-tagged | +Inquiry |
IDUA-569H | Recombinant Human IDUA Protein (28-653 aa), His-tagged | +Inquiry |
Idua-4418M | Recombinant Mouse Idua Protein, His (Fc)-Avi-tagged | +Inquiry |
IDUA-995H | Recombinant Human IDUA Protein, MYC/DDK-tagged | +Inquiry |
IDUA-196H | Recombinant Human IDUA Protein, His-tagged | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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