Recombinant Mouse Ntrk2 Protein, His-tagged

• Cat.No.: Ntrk2-359M
• Product Overview: Recombinant mouse NTRK2, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Specification

• Description: NTRK2, also known as BDNF/NT-3 growth factors receptor, is a member of the neurotrophic tyrosine receptor kinase family. This protein involves in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, differentiation, and synapse formation and plasticity.
• Source: Insect cell
• Species: Mouse
• Tag: His
• Form: In Phosphate Buffered Saline (pH 7.4) containing 10% glycerol.
• Molecular Mass: 45.7kDa (409aa)57-70KDa (SDS-PAGE under reducing conditions.)
• AA Sequence: CPTSCKCSSA RIWCTEPSPG IVAFPRLEPN SVDPENITEI LIANQKRLEI INEDDVEAYV GLRNLTIVDS GLKFVAYKAF LKNSNLRHIN FTRNKLTSLS RRHFRHLDLS DLILTGNPFT CSCDIMWLKT LQETKSSPDT QDLYCLNESS KNMPLANLQI PNCGLPSARL AAPNLTVEEG KSVTLSCSVG GDPLPTLYWD VGNLVSKHMN ETSHTQGSLR ITNISSDDSG KQISCVAENL VGEDQDSVNL TVHFAPTITF LESPTSDHHW CIPFTVRGNP KPALQWFYNG AILNESKYIC TKIHVTNHTE YHGCLQLDNP THMNNGDYTL MAKNEYGKDE RQISAHFMGR PGVDYETNPN YPEVLYEDWT TPTDIGDTTN KSNEIPSTDV ADQSNREHAA ALEHHHHHH
• Endotoxin: < 1.0 EU per 1 microgram of protein (determined by LAL method)
• Purity: >95% by SDS - PAGE
• Storage: Can be stored at +4 centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20 centigrade or -70 centigrade. Avoid repeated freezing and thawing cycles.
• Concentration: 0.5mg/ml (determined by Absorbance at 280nm)

Gene Information

• Gene Name: Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 [ Mus musculus ]
• Official Symbol: Ntrk2
• Synonyms: NTRK2; neurotrophic tyrosine kinase, receptor, type 2; BDNF/NT-3 growth factors receptor; trk-B; GP145-TrkB/GP95-TrkB; trkB tyrosine kinase; Tkrb; trkB; AI848316; C030027L06Rik
• Gene ID: 18212
• mRNA Refseq: NM_001025074
• Protein Refseq: NP_001020245
• Pathway: Activation of TRKA receptors, organism-specific biosystem; MAPK signaling pathway, organism-specific biosystem; MAPK signaling pathway, conserved biosystem; NGF signalling via TRKA from the plasma membrane, organism-specific biosystem; NGF-independant TRKA activation, organism-specific biosystem; Neurotrophin signaling pathway, organism-specific biosystem; Neurotrophin signaling pathway, conserved biosystem
• Function: ATP binding; brain-derived neurotrophic factor binding; brain-derived neurotrophic factor binding; brain-derived neurotrophic factor-activated receptor activity; brain-derived neurotrophic factor-activated receptor activity; kinase activity; neurotrophin receptor activity; neurotrophin-3 binding; neurotrophin-3 binding; neurotrophin-4/5 binding; nucleotide binding; protein binding; protein homodimerization activity; protein kinase activity; protein tyrosine kinase activity; receptor activity; transferase activity; transferase activity, transferring phosphorus-containing groups; transmembrane receptor protein tyrosine kinase activity