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Home > Products > Recombinant Proteins > Recombinant Mouse PVRIG protein, Fc-tagged

Recombinant Mouse PVRIG protein, Fc-tagged

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Human(9)
Mouse(1)
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Fc(2)
GST(1)
His(1)
His/SUMO(1)
Cat.No.:
PVRIG-12M
Product Overview:
The extracellular domain of mouse CD112R (aa 28-165) fused with the C-terminus to the Fc portion of human IgG1 was expressed in HEK 293 cells.
Description:
CD112 (also called Nectin-2 or poliovirus receptor-related 2 protein) is a type I transmembrane glycoprotein and a member of the Ig gene superfamily (IGSF). CD112/Nectin-2 functions as an adhesion molecule involved in the formation of cell junctions and interactions with other Nectin-family molecules. Nectin-2 is a also a surface marker of some endothelial cells and regulates migration, proliferation and angiogenesis. CD112 functions as an immune checkpoint regulator by modulating T cell signaling, either as a costimulator of T cell function, or as a coinhibitor of T cells proliferation by binding to the receptors CD226 or TIGIT (T cell Ig and immunoreceptor tyrosine-based inhibitory motif (ITIM) domain), respectively. The binding of CD112 ligand to these receptors is weak compared to CD155. Recently, a new receptor of CD112, called CD112R or PVRIG (Poliovirus receptor-related immunoglobulin domain-containing protein) has been characterized, showing high affinity to CD112. CD112R is a new coinhibitory receptor of the PVR family for human T cells, inhibiting TCR-mediated signals upon binding to CD112/Nectin-2. CD112R is preferentially expressed in T lymphocytes and NK cells. Cancer cells evade immune responses as a result of an immunosuppressive tumor microenvironment and CD112R, by playing a role in the regulation of the immune system, could be a new attractive cancer immunotherapy target.
Source:
HEK293 cells
Species:
Mouse
Tag :
Fc
Form:
Lyophilized. Contains PBS.
Bio-activity:
Binds to the ligand mouse CD112 (PVRL2, Nectin-2) with an EC50 of 5nM.
Molecular Mass:
~48-50 kDa (SDS-PAGE)
Endotoxin:
<0.01EU/μg purified protein (LAL test)
Purity:
>90% (SDS-PAGE)
Stability:
Stable for at least 6 months after receipt when stored at -20 centigrade.
Storage:
Short term store at +4 centigrade, store at -20 centigrade for long term storage.
Concentration:
0.1mg/mL after reconstitution.
Reconstitution:
Reconstitute with 100 μL sterile water.
Handling:
After reconstitution, prepare aliquots and store at -20 centigrade. Avoid freeze/thaw cycles. PBS containing at least 0.1% BSA should be used for further dilutions.


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Optional requirements on this protein +Expand
C-fusion   N-fusion  Non-tagged
His   GST  Fc  Others
<1.0 eu/μg   <0.1 eu/μg  <0.01 eu/μg  Not required
Monomer Isolation   Dimer Isolation   Not required
>80% by SDS-PAGE   >90% by SDS-PAGE  >95% by SDS-PAGE  Others
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45-1 Ramsey Road, Shirley, NY 11967, USA
USA: 1-631-559-9269  1-631-448-7888
Europe: 44-207-048-3343
FAX: 1-631-938-8127
EMAIL: info@creative-biomart.com

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