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Active Recombinant Mouse SDC2 Protein

Cat.No. : SDC2-14790M
Product Overview : Recombinant mouse Syndecan-2 (Glu19-Phe141) protein with C-terminal TGHHH HHHHHGGQ was expressed in HEK293 cell.
  • Specification
  • Gene Information
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Description : Syndecan-2, previously known as fibroglycan, is a member of the syndecan family of Type 1 transmembrane proteins carrying heparan sulfate and chondroitin sulfate glycosaminoglycans. The syndecan family consists of four transmembrane proteoglycans divided into two subfamilies (Syndecan -1 , -3 and Syndecan-2 ,- 4) based on their sequence homology. The four syndecans have conserved cytoplasmic domains which enables them to associate with cytoskeletal proteins and signaling molecules. The cytoplasmic tail of Syndecan-2 has both serine and tyrosine phosphorylation sites. Non-covalent homodimerization of Syndecan-2 is dependent on the transmembrane domain. Syndecan-2 is expressed in endothelial, mesenchymal, carcinoma cells, and is the predominant syndecan expressed during embryonic development. It functions as a co-receptor for enzymes, growth factors, and cytokines, and contributes to the formation of cytokine gradients through extracellular shedding. Syndecan-2 interacts with high affinity receptors and integrins to modulate intracellular signaling. Syndecan is also involved in matrix assembly and remodeling. It controls laminin and fibronectin matrix assembly into a fibrillar matrix.
Source : HEK293
Species : Mouse
Bio-activity : When mouse Syndecan-2 is immobilized at 5 μg/mL, human FGF-basic binds with EC50 of 2 - 8 ng/mL.
Molecular Mass : 14.9 kDa
N-terminal Sequence Analysis : Glu
Endotoxin : Less than 0.1 EU per μg of protein as determined by the LAL method.
Purity : >95% as determined by Coomassie stained SDS-PAGE.
Applications : Bioassay
Storage : Unopened vial can be stored between 2 centigrade and 8 centigrade for one month, at -20 centigrade for six months, or at -70 centigrade for one year. For maximum results, quick spin vial prior to opening. The protein can be aliquoted and stored at -20 centigrade to -70 centigrade. Stock solutions can also be prepared at 50 - 100 μg/mL in sterile buffer (PBS, HPBS, DPBS, or EBSS) containing carrier protein such as 0.2-1% BSA or HSA and stored in working aliquots at -20 centigrade to -70 centigrade. Avoid repeated freeze/thaw cycles.
Concentration : 200 μg/mL
Storage Buffer : 0.22 μm filtered protein solution is in PBS, pH 7.2.
Gene Name : Sdc2 syndecan 2 [ Mus musculus (house mouse) ]
Official Symbol : Sdc2
Synonyms : SDC2; Synd2; Hspg1; Fibroglycan; Hspg1; Synd2; AA960457; syndecan-2; 4833414L08Rik; syndecan-2; HSPG; fibroglycan; heparan sulfate proteoglycan 1, cell surface-associated (fibroglycan); heparan sulfate proteoglycan core protein
Gene ID : 15529
mRNA Refseq : NM_008304
Protein Refseq : NP_032330
UniProt ID : P43407

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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