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Active Recombinant Mouse Tek Protein, Fc-tagged

Cat.No. : Tek-959M
Product Overview : Recombinant mouse Tek (NP_038718.2) (Met1-Lys744) was expressed with the Fc region of human IgG1 at the C-terminus.
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  • Gene Information
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Source : HEK293
Species : Mouse
Tag : Fc
Predicted N Terminal : Val 19
Form : Lyophilized from sterile PBS, pH 7.4, 5%~8% trehalose and mannitol.
Bio-activity : 1. Measured by its binding ability in a functional ELISA. 2. Immobilized mouse ANGPT2 at 10 μg/mL (100 μL/well) can bind mouse TEK-Fc. The EC50 of mouse TEK-Fc is 0.58-1.34 μg/mL.
Molecular Mass : The recombinant mouse Tek consists 964 amino acids and predicts a molecular mass of 107.7 kDa.
Endotoxin : < 1.0 EU per μg of the protein as determined by the LAL method.
Purity : >95 % as determined by SDS-PAGE.
Stability : Samples are stable for up to twelve months from date of receipt at -70ºC.
Storage : Store it under sterile conditions at -20ºC~-70ºC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.25 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.
Gene Name : Tek endothelial-specific receptor tyrosine kinase [ Mus musculus ]
Official Symbol : Tek
Synonyms : TEK; endothelial-specific receptor tyrosine kinase; angiopoietin-1 receptor; STK1; mTIE2; p140 TEK; endothelial tyrosine kinase; tyrosine-protein kinase receptor TEK; tunica interna endothelial cell kinase; tyrosine-protein kinase receptor TIE-2; tyrosine
Gene ID : 21687
mRNA Refseq : NM_013690
Protein Refseq : NP_038718
MIM :
UniProt ID :
Pathway : Cell surface interactions at the vascular wall, organism-specific biosystem; Hemostasis, organism-specific biosystem; Rheumatoid arthritis, organism-specific biosystem; Rheumatoid arthritis, conserved biosystem; Tie2 Signaling, organism-specific biosystem
Function : ATP binding; growth factor binding; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein tyrosine kinase activity; protein tyrosine kinase activity; receptor activity; transferase activity; transferase activity, transferr

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does the TEK gene influence vascular development during embryogenesis, and what are the key molecular players involved? 09/26/2021

The TEK gene is crucial for vascular development during embryogenesis, coordinating with other genes and signaling pathways to ensure proper formation of the vascular system.

What role does the TEK gene play in pathological angiogenesis, particularly in diseases like cancer? 06/15/2020

The TEK gene is implicated in pathological angiogenesis in diseases like cancer, where dysregulation of TIE2 signaling can contribute to aberrant blood vessel formation.

How does the TEK gene contribute to the modulation of vascular permeability? 12/07/2019

The TEK gene, through TIE2 signaling, regulates vascular permeability by influencing the integrity of endothelial cell junctions and controlling the passage of molecules across blood vessels.

How does the TEK gene contribute to the maintenance of vascular quiescence, and what molecular processes are involved? 08/04/2019

The TEK gene contributes to the maintenance of vascular quiescence by suppressing endothelial cell activation and inflammation, preserving the stability of blood vessels.

How does the TEK gene participate in the regulation of immune responses in the context of vascular inflammation? 03/05/2018

The TEK gene, through TIE2 signaling, influences immune responses by modulating interactions between endothelial cells and immune cells during vascular inflammation.

Customer Reviews (3)

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Reviews
06/07/2020

    Outstanding service! Staff expertise helped us choose the perfect protein.

    10/31/2019

      Seamless delivery process—ordered, received, and ready for experiments.

      03/14/2018

        Courteous and efficient customer service made our purchase hassle-free.

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