Recombinant Mouse Tnfrsf9 protein, His-tagged
Cat.No. : | Tnfrsf9-82M |
Product Overview : | Recombinant mouse TNFRSF9, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. |
- Specification
- Gene Information
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Description : | TNFRSF9, also known as tumor necrosis factor receptor superfamily member 9, interacts with TNFSF9 expressed on activated T cells and delivers a co-stimulatory signal for T cell activation and growth. It binds with high affinity to the transmembrane TNFSF9(4-1BB ligand) which expressed on antigen presenting cells and myeloid progenitor cells. |
Source : | Insect cell |
Species : | Mouse |
Tag : | His |
Form : | Liquid. In Phosphate Buffered Saline (pH 7.4) containing 10% glycerol. |
Molecular Mass : | 18.6kDa (172aa)18-28KDa (SDS–PAGE under reducing conditions.) |
AA Sequence : | VQNSCDNCQP GTFCRKYNPV CKSCPPSTFS SIGGQPNCNI CRVCAGYFRF KKFCSSTHNA ECECIEGFHC LGPQCTRCEK DCRPGQELTK QGCKTCSLGT FNDQNGTGVC RPWTNCSLDG RSVLKTGTTE KDVVCGPPVV SFSPSTTISV TPEGGPGGHS LQVLLEHHHH HH |
Endotoxin : | < 1.0 EU per 1 microgram of protein (determined by LAL method) |
Purity : | >90% by SDS – PAGE |
Storage : | Can be stored at +4 centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20 centigrade or -70 centigrade. Avoid repeated freezing and thawing cycles. |
Concentration : | 0.5mg/ml (determined by Absorbance at 280nm) |
Gene Name : | Tnfrsf9 tumor necrosis factor receptor superfamily, member 9 [ Mus musculus ] |
Official Symbol : | Tnfrsf9 |
Synonyms : | TNFRSF9; tumor necrosis factor receptor superfamily, member 9; tumor necrosis factor receptor superfamily member 9; CD137 antigen; T-cell antigen 4-1BB; 4-1BB ligand receptor; secreted CD137 antigen; ILA; Ly63; 4-1BB; Cd137; CDw137; AA408498; AI325004; A930040I11Rik; |
Gene ID : | 21942 |
mRNA Refseq : | NM_001077508 |
Protein Refseq : | NP_001070976 |
MIM : | |
UniProt ID : | |
Pathway : | Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; |
Function : | binding; receptor activity; |
Products Types
◆ Recombinant Protein | ||
TNFRSF9-582M | Recombinant Mouse TNFRSF9 Protein | +Inquiry |
TNFRSF9-315H | Recombinant Human TNFRSF9 Protein (ECD), Fc-His-tagged(C-ter) | +Inquiry |
TNFRSF9-550R | Active Recombinant Rhesus TNFRSF9 Protein, His-tagged | +Inquiry |
TNFRSF9-583M | Recombinant Mouse TNFRSF9 Protein, Fc-tagged | +Inquiry |
TNFRSF9-076H | Recombinant Human TNFRSF9 Protein, C-His-tagged | +Inquiry |
◆ Lysates | ||
TNFRSF9-928CCL | Recombinant Canine TNFRSF9 cell lysate | +Inquiry |
TNFRSF9-1792MCL | Recombinant Mouse TNFRSF9 cell lysate | +Inquiry |
TNFRSF9-2162HCL | Recombinant Human TNFRSF9 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionStudies have found that abnormal expression levels of TNFRSF9 may be associated with certain tumors, autoimmune diseases, and inflammatory diseases.
It has a variety of associations with other proteins and cytokines. For example, it may interact with the NF-kB signaling pathway to regulate the inflammatory response, and it may also interact with apoptosis-related proteins to regulate the apoptosis process.
TNFRSF9 mainly plays an important role in the immune system, as an activating signaling molecule, it is able to stimulate the activation, proliferation and survival of T cells and NK cells.
Inhibitors or activators targeting TNFRSF9 may have potential applications for the treatment of certain tumors, autoimmune diseases, and inflammatory diseases.
The extracellular domain of TNFRSF9 can bind to its ligand, such as 4-1BBL, to initiate signal transduction, which in turn activates downstream signaling pathways.
TNFRSF9 has some potential in tumor immunotherapy. Several antibody drugs have been developed to use the stimulating effects of TNFRSF9 to enhance the activity of immune cells to fight tumors.
Customer Reviews (3)
Write a reviewGood heat resistance, long time treatment at high temperature, still has activity.
The results obtained by SDS-PAGE or Western blot analysis were good.
The purity is good, and the experimental results obtained are accurate.
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