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Recombinant Rat ADI1 Protein

Cat.No. : ADI1-528R
Product Overview : Recombinant Rat ADI1 full length or partial length protein was expressed.
  • Specification
  • Gene Information
  • Related Products
Source : Mammalian Cells
Species : Rat
Tag : His
Form : Liquid or lyophilized powder
Endotoxin : < 1.0 EU per μg of the protein as determined by the LAL method.
Purity : >80%
Notes : This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
Storage : Store it at +4 ºC for short term. For long term storage, store it at -20 ºC~-80 ºC.
Storage Buffer : PBS buffer
Gene Name : Adi1 acireductone dioxygenase 1 [ Rattus norvegicus ]
Official Symbol : ADI1
Gene ID : 298934
mRNA Refseq : NM_199097.1
Protein Refseq : NP_954528.1
MIM :
UniProt ID : Q562C9

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (12)

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Can ADI1 protein be targeted for therapeutic purposes? 12/03/2022

There is limited evidence for the potential therapeutic targeting of ADI1 protein. However, some studies have suggested that modulating its activity could have potential therapeutic effects in certain diseases, such as cancer and neurodegenerative disorders. For example, ADI1 inhibitors have been shown to have cytotoxic effects on cancer cells, and ADI1-overexpressing cells have been found to be more resistant to oxidative stress-induced cell death. Further research is needed to determine the therapeutic potential of targeting ADI1 protein.

Are there any drugs currently targeting ADI1 protein? 11/12/2021

There are currently no drugs targeting ADI1 protein approved for clinical use. However, some compounds have been identified that can inhibit ADI1 activity, such as plant extracts and synthetic compounds. These compounds have shown some promise as potential anticancer agents in preclinical studies, but more research is needed to determine their efficacy and safety.

Is ADI1 protein involved in mitochondrial function? 09/22/2021

Yes, ADI1 has been shown to be involved in mitochondrial function. Specifically, it is localized to the inner mitochondrial membrane and has been found to modulate mitochondrial membrane potential and oxidative phosphorylation. It has also been shown to function as a regulator of mitochondrial morphology and dynamics. However, more research is needed to fully understand the role of ADI1 in mitochondrial function.

How is ADI1 protein regulated? 08/09/2021

ADI1 protein is regulated at multiple levels, including post-transcriptional, post-translational, and protein-protein interaction mechanisms. For example, ADI1 expression can be regulated by microRNAs, and its activity can be modulated by phosphorylation and other post-translational modifications. Its interaction with other proteins, such as p53, also regulates its activity.

Is ADI1 protein involved in any cellular processes? 08/05/2021

Yes, ADI1 protein is involved in various cellular processes, including energy metabolism, redox regulation, and cell signaling. Its primary function is as an enzyme that catalyzes the oxidation of several small molecules, including 2,4-dienoyl-CoA, quinines, and hydroxysteroids. It also has antioxidant activity and has been shown to regulate the activity of transcription factors and signaling pathways, such as p53 and the MAPK pathway.

Can ADI1 protein be a potential target for cancer therapy? 06/29/2020

Yes, ADI1 protein has been proposed as a potential target for cancer therapy. Its involvement in both tumor suppression and progression suggests that it may be a key regulator of cancer cell survival and proliferation. Small molecule inhibitors of ADI1 have been developed and tested in preclinical studies, with promising results in inhibiting tumor growth and invasion.

Is ADI1 protein expressed in all tissues? 04/19/2019

ADI1 protein is expressed in many tissues, but its expression levels can vary. For example, ADI1 is highly expressed in liver, kidney, and testes, but is expressed at lower levels in other tissues such as brain and heart. Its expression has also been detected in cancer cells and has been shown to be upregulated in certain cancers.

Is ADI1 protein involved in any diseases or disorders? 11/04/2018

Yes, ADI1 protein has been implicated in various diseases and disorders. For example, mutations in the ADI1 gene have been associated with autosomal recessive cerebellar ataxia, a neurological disorder characterized by progressive loss of coordination and movement control. ADI1 has also been implicated in cancer, as discussed earlier.

Is ADI1 protein expressed in all tissues? 12/29/2017

ADI1 protein is expressed in a variety of tissues, including liver, kidney, lung, and brain. However, its expression levels can vary between tissues and cell types.

Is ADI1 protein conserved across species? 04/24/2017

Yes, ADI1 protein is highly conserved across species, from bacteria to humans. This conservation suggests that it plays an important and evolutionarily conserved role in cellular processes.

Can ADI1 protein be used as a biomarker for disease diagnosis or prognosis? 03/01/2017

There is limited evidence for the use of ADI1 protein as a biomarker for disease diagnosis or prognosis. However, some studies have suggested that its expression levels may be altered in certain diseases, such as prostate cancer and Alzheimer's disease. Further research is needed to determine its potential utility as a biomarker.

How does ADI1 protein regulate p53-mediated apoptotic pathways? 07/30/2016

ADI1 protein interacts with p53 and modulates its transcriptional activity, resulting in the upregulation of pro-apoptotic genes and the downregulation of anti-apoptotic genes. This promotes the activation of the apoptotic pathway and can lead to cell death in response to cellular stress.

Customer Reviews (5)

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Reviews
11/29/2022

    the purity of the protein has exceeded our expectations, with minimal interference caused by contaminants or impurities.

    09/03/2022

      The protein is highly stable and able to maintain its activity even after being subjected to harsh conditions, which is crucial for carrying out rigorous biochemical assays.

      05/25/2022

        the quality of ADI1 protein combined with the manufacturer's outstanding support has proved to be a valuable asset to the study.

        10/25/2017

          the company's efficient and prompt delivery process has ensured that the protein arrived in excellent condition, allowing for immediate use in our experiments.

          07/17/2016

            we are impressed with both the quality of the protein and the outstanding technical support provided by the manufacturer.

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