Active Recombinant Rat Btk protein, GST-tagged
Cat.No. : | Btk-185R |
Product Overview : | Recombinant Rat Btk fused with GST tag at N-terminal was expressed in Insect cells. |
- Specification
- Gene Information
- Related Products
Description : | BTK (also known as Bruton tyrosine kinase) plays a crucial role in B-lymphocyte differentiation and activation. BTK interacts with SRC homology 3 domains of FYN, LYN and HCK that are activated upon stimulation of B- and T-cell receptors.Defects in the BTK gene cause Agammaglobulinemia, an X-linked immunodeficiency characterized by failure to produce mature B lymphocyte cells and associated with a failure of Ig heavy chain rearrangement. The unique role of BTK makes it a desirable target for potential anti-cancer, anti-inflammatory and anti-viral agents as well as other treatments. |
Source : | Insect cells |
Species : | Rat |
Tag : | GST |
Form : | 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol. |
Bio-activity : | 66 nmol/min/mg |
Molecular Mass : | ~105 kDa |
Purity : | >95% |
Applications : | Kinase Assay, Western Blot |
Stability : | 1yr at –70 centigrade from date of shipment |
Storage : | Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Concentration : | 0.1 µg/µl |
Gene Name : | Btk Bruton agammaglobulinemia tyrosine kinase [ Rattus norvegicus ] |
Official Symbol : | Btk |
Synonyms : | BTK; Bruton agammaglobulinemia tyrosine kinase; tyrosine-protein kinase BTK; |
Gene ID : | 367901 |
mRNA Refseq : | NM_001007798 |
Protein Refseq : | NP_001007799 |
Chromosome Location : | Xq34 |
Pathway : | B Cell Receptor Signaling Pathway, organism-specific biosystem; B cell receptor signaling pathway, organism-specific biosystem; B cell receptor signaling pathway, conserved biosystem; Fc epsilon RI signaling pathway, organism-specific biosystem; Fc epsilon RI signaling pathway, conserved biosystem; IL-5 Signaling Pathway, organism-specific biosystem; IL-6 Signaling Pathway, organism-specific biosystem; |
Function : | identical protein binding; phosphatidylinositol-3,4,5-trisphosphate binding; protein tyrosine kinase activity; protein tyrosine kinase activity; |
Products Types
◆ Recombinant Protein | ||
Btk-723M | Recombinant Mouse Btk Protein, MYC/DDK-tagged | +Inquiry |
BTK-2827H | Recombinant Human BTK Protein, MYC/DDK-tagged | +Inquiry |
BTK-26220TH | Active Recombinant Human BTK protein | +Inquiry |
BTK-457H | Recombinant Human BTK Protein, His (Fc)-Avi-tagged | +Inquiry |
BTK-0743H | Recombinant Human BTK Protein (M1-S659), Tag Free | +Inquiry |
◆ Lysates | ||
BTK-001HCL | Recombinant Human BTK cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-1569 | BTK Kinase Binding Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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