Recombinant Rhesus monkey ABCC2 Protein, His-tagged
Cat.No. : | ABCC2-180R |
Product Overview : | Recombinant Rhesus monkey ABCC2 full length or partial length protein was expressed. |
- Specification
- Gene Information
- Related Products
Source : | Mammalian Cells |
Species : | Rhesus monkey |
Tag : | His |
Form : | Liquid or lyophilized powder |
Endotoxin : | < 1.0 EU per μg of the protein as determined by the LAL method. |
Purity : | >80% |
Notes : | This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications. |
Storage : | Store it at +4 ºC for short term. For long term storage, store it at -20 ºC~-80 ºC. |
Storage Buffer : | PBS buffer |
Gene Name : | ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 [ Macaca mulatta (Rhesus monkey) ] |
Official Symbol : | ABCC2 |
Synonyms : | ABCC2; mrp2; canalicular multispecific organic anion transporter 1; multidrug resistance protein MRP2; |
Gene ID : | 574169 |
mRNA Refseq : | NM_001032847 |
Protein Refseq : | NP_001028019 |
MIM : | |
UniProt ID : | Q95L75 |
Products Types
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (15)
Ask a questionCry1Ca is a protein that belongs to the family of crystal (Cry) proteins produced by the bacterium Bacillus thuringiensis.Some reseachs show that Cry1Ca could decrease the transport function of ABCC2 in plant.
Carriage of the ABCC2 (MRP2) rs717620 T variant may increase the risk of hyperbilirubinemia and mortality in patients with DILI.
Yes, Dubin-Johnson syndrome (DJS) is a hereditary condition, which means it is passed down through families.
Causes Dubin-Johnson syndrome is caused by changes in a gene known as ABCC2. The ABCC2 gene provides instructions for making a protein that transports certain substances out of cells so they can be released (excreted) from the body.
ABCC2 and ABCC3 (also known as MRP2 and MRP3) mediate the transport of various conjugated organic anions, including many drugs, toxicants and endogenous compounds.
ABCC2/Abcc2 (MRP2/Mrp2) is expressed at major physiological barriers, such as the canalicular membrane of liver cells, kidney proximal tubule epithelial cells, enterocytes of the small and large intestine, and syncytiotrophoblast of the placenta.
ABCC2/Abcc2 transports a variety of amphiphilic anions that belong to different classes of molecules, such as endogenous compounds (e.g., bilirubin-glucuronides), drugs, toxic chemicals, nutraceuticals, and their conjugates.
The ABCC2 c.-24C>T polymorphism is a likely risk factor for resistance to AEDs.
Some researchs show that the ABCC2 G1249A polymorphism is significantly associated with a decreased risk of AED resistance. However, further functional investigations are warranted to validate the association.
Acquired or hereditary deficiency of ABCC2, the latter known as Dubin-Johnson syndrome in humans
It is possible that ABCC2/Abcc2 transport activity as well as inhibitor sensitivity could lead to a number of phenomena (e.g. a difference in the biliary excretion clearance, a delay in the elimination half-life from the circulating blood and toxic side effects on ABCC2 -mediated drug-drug interactions, such as drug-induced hyperbilirubinemia).
Human ABCC2 is an ATP-binding cassette transporter involved in the export of endobiotics and xenobiotics. It is involved in cisplatin resistance in cancer cells, particularly in ovarian cancer.
ABCC2 is a member of the multidrug resistance protein subfamily localized exclusively to the apical membrane domain of polarized cells, such as hepatocytes, renal proximal tubule epithelia, and intestinal epithelia.
The hepatic ABCC2 pump contributes to the driving forces of bile flow.
Customer Reviews (3)
Write a reviewComplete packaging and fast transportation
Good positioning effect
Less clutter and clear background
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