Recombinant Rhesus IFNAR1 Protein, His-tagged

• Cat.No.: IFNAR1-2205R
• Product Overview: Recombinant Rhesus IFNAR1(Met1-Lys436) fused with His tag at C-terminal was expressed in HEK293.

Specification

• Description: Interferon-alpha/beta receptor alpha chain (IFNAR1) is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. Tyk2 slows down IFNAR1 degradation and that this is due, at least in part, to inhibition of IFNAR1 endocytosis. Mutant versions of IFNAR1, in which Tyr466 is changed to phenylalanine, can act in a dominant negative manner to inhibit phosphorylation of STAT2. These observations are consistent with a model in which IFNAR1 mediates the interaction between JAK kinases and the STAT transcription factors.
• Source: HEK293
• Species: Rhesus
• Tag: His
• Predicted N Terminal: Lys 28
• Form: Lyophilized from sterile PBS, pH 7.4
  1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
  2. Please contact us for any concerns or special requirements.
• Molecular Mass: The recombinant rhesus IFNAR1 comprises 421 amino acids and has a calculated molecular mass of 48.7 KDa.
• Protein length: Met1-Lys436
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
• Purity: > 90 % as determined by SDS-PAGE
• Stability: Samples are stable for up to twelve months from date of receipt at -70 centigrade
• Storage: Store it under sterile conditions at -20 centigrade to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Reconstitution: Reconstitute in sterile water to a concentration of 0.1-1.0 mg/mL. Do not vortex.
• Shipping: In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
  Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.

Gene Information

• Gene Name: IFNAR1 interferon alpha and beta receptor subunit 1 [ Macaca mulatta ]
• Official Symbol: IFNAR1
• Synonyms: IFNAR1; interferon alpha/beta receptor 1
• Gene ID: 699604
• mRNA Refseq: NM_001266513
• Protein Refseq: NP_001253442