Address: 45-1 Ramsey Road, Shirley, NY 11967, USA    USA: 1-631-559-9269  1-631-448-7888   Fax: 1-631-938-8127  Europe: 44-207-097-1828   Email:
Home > Products > Assay Kits > Activity Kits > Universal Methyltransferase Activity Assay Kit

Universal Methyltransferase Activity Assay Kit

"Methyltransferase" Related Products.
Product Overview:
Universal Methyltransferase Activity Assay Kit is a homogeneous mix-and-read fluorescent assay for the determination of any S-adenosyl-L-methionine (AdoMet/SAM) dependent methyltransferase activity. It is suitable for end-point or kinetic read options, which is ideal for determining mechanism of action, kinetics, and screening candidate compounds. The assay is amendable to HTS and miniaturization. The kit is a complete kit for the screening of candidate compounds that may alter normal methyltransferase activity.
1 x 96 tests
Methylation of proteins, nucleic acids and oligosaccharides is an important post-translational regulatory event. Activities that are methylation-related include meiosis, biosynthesis, development, signal transduction, chromatin regulation, and gene silencing. The enzymes that mediate the covalent transfer of a methyl group from a donor to an acceptor molecule are methyltransferases. Methyltransferases have structurally unrelated acceptors as diverse as proteins and DNA, however frequently use S-adenosylmethionine as a universal donor. Part of the acceptor diversity of this enzyme family relates to the flexible structural folds that bind these molecules in proximity of the donor. The side-chains of lysine, arginine, glutamate, glutamine, asparagines, and isoprenylated residues serve as methylation sites in proteins like histones. Changes in methylation patterns have been tightly linked to disease states such as cancer and vascular disease.
Functional Studies more details
Kit Components:
Components: 1 x 96 tests; Black Microtiter Plate: 1 unit; Methyltransferase Positive Control: 1 x 0.2ml; Methyltransferase Reaction Buffer Concentrate: 1 x 0.3ml; Plate Sealer: 1 x 3 units; Transferase Assay Buffer Concentrate: 1 x 15ml; Transferase Detection Solution Concentrate: 1 x 0.15ml
Compatible Sample Types:
Purified protein

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Note: There will be extra charge for optional service!
Optional requirements on this protein +Expand
C-fusion   N-fusion  Non-tagged
His   GST  Fc  Others
<1.0 eu/μg   <0.1 eu/μg  <0.01 eu/μg  Not required
Monomer Isolation   Dimer Isolation   Not required
>80% by SDS-PAGE   >90% by SDS-PAGE  >95% by SDS-PAGE  Others
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45-1 Ramsey Road, Shirley, NY 11967, USA
USA: 1-631-559-9269  1-631-448-7888
Europe: 44-207-097-1828
FAX: 1-631-938-8127

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