Methionine Adenosyltransferase II alpha Related Researches and Products
Methionine adenosyltransferase II alpha (MAT2A) is an essential enzyme that is in charge of S-adenosylmethionine (SAMe) biosynthesis. It is extensively distributed within body.
In liver, increased MAT2A expression correlates with growth, while SAMe inhibits MAT2A expression and growth. Thus some researchers studied the relationship between MAT2A and color cancer in mice and found that upregulation of MAT2A provides a growth advantage and SAMe and MTA can block mitogenic signaling in colon cancer cells.
There were also reports showing the deficiency of MAT2A leading to persistent hypermethioninemia without elevation of plasma S-
Thereafter, researchers made more and more MAT2A-related research, such as “Inhibition of methionine adenosyltransferase II induces FasL expression, Fas-DISC formation and caspase-8-dependent apoptotic death in T leukemic cells”, “Ethanol inhibits methionine adenosyltransferase II activity and S-adenosylmethionine biosynthesis and enhances caspase-3-dependent cell death in T lymphocytes: relevance to alcohol-induced immunosuppression” and so many others.
Article Link: Methionine Adenosyltransferase II alpha Related Researches and Products
