"Protein" Related Products

Antibody/Protein Aggregation Assay Kit

Cat.No.: Kit-1088
Description: Antibody and protein aggregation are important issues in the field of Biotherapeutics. A wide range of conditions and different stages of processing of biopharmaceuticals, such as, formulation, purification, storage, shipping and handling, heat, freeze thaw cycles, mechanical stress, chemical trea;ent etc. might cause aggregation of proteins, enzymes and antibody targets. The possibility of protein aggregates in eliciting immunogenicity is a major concern for biotherapeutics, which might compromise the safety and efficacy of the biologically derived drug products. Recombinant protein production and storage would highly benefit from a high throughput screening method that can screen a variety of formulation and storage conditions of a particular target proteintibody. Currently, different biophysical techniques such as Dynamic Light Scattering (DLS), Size-exclusion Chromatography with Multi-angle Light Scattering (SEC-MALS) can detect the presence of small amount of aggregates in a proteintibody preparation, but they are not amenable for high-throughput screening format. Antibody/Protein Aggregation assay kit is a platform to estimate the extent of aggregation within a proteintibody sample. This is a fast, high-throughput, plate-based fluorometric assay format and can detect as low as 0.5% antibody aggregate.
Applications: Measurement of protein aggregation for protein formulation
Storage: -20°C
Shipping: Gel Pack
Size: 100 assays
Kit Components: Aggregation Assay Buffer; Antibody aggregate standard (0%); Antibody aggregate standard (10%); Aggregation Assay Probe
Detection method: Detection method- Fluorescence (Ex/Em = 440/500 nm)
Features & Benefits: Simple one-step procedure; takes less than one hour;
High-throughput compatible;
The entire assay can be performed directly in a 96-well plate and does not require washing/long incubation times or solubilization steps

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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