Aurora Family Kinase (Human) Assay/Inhibitor Screening Kit
Cat.No. : | Kit-0122 |
Product Overview : | Aurora Family Kinase (Human) Assay/Inhibitor Screening Kit is a single-site, non-quantitative immunoassay for Aurora A, B and C kinase activity. Plates are pre-coated with a recombinant "Aurora-substrate-1" which contains a serine residue that is phosphorylated by Aurora A, B and C kinase. The detector antibody specifically detects only the phosphorylated form of "Aurora-substrate-1". |
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Applications : | 1) Screening inhibitors or activators of Aurora A, B and C kinase.2) Detecting the effects of pharmacological agents on Aurora A, B and C kinase activity. |
Storage : | • Upon receipt store the ATP at -20°C• Upon receipt store all other components at 4°C; Do not expose reagents to excessive light |
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionAurora protein is involved in the regulation of apoptosis and DNA damage repair, but the specific mechanism needs to be further studied.
It is a potential target for anticancer therapy due to its important role in tumors. Researchers are developing inhibitors against the Aurora protein to treat cancer.
The abnormal expression or mutation of Aurora protein is closely related to the occurrence and development of tumors, and its overexpression may lead to abnormal cell proliferation and chromosome instability.
The activity of Aurora protein is regulated by phosphorylation modification, and changes in phosphorylation state can affect its substrate binding ability and catalytic activity.
Aurora proteins play important roles in different phases of the cell cycle, including the regulation of the cell cycle, chromosome segregation, and the progression of cell mitosis.
The phosphorylation substrates of Aurora proteins include chromosome-associated proteins, cytoskeletal proteins and other cell cycle regulatory proteins.
Customer Reviews (3)
Write a reviewBeacuse expression was very high and could be easily detected.
The production is very high and can meet a lot of my needs.
This background was very clean and not immunogenic.
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