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AVPR1B CHO-K1 β-Arrestin GPCR Assay Kit

Cat.No. : Kit-1122
Product Overview : β-Arrestin GPCR cells are engineered to co-the ProLink (PK) tagged GPCR and the Enzyme Acceptor (EA) tagged β-Arrestin. Activation of the GPCR-PK induces β-Arrestin-EA recruitment, forcing complementation of the two β-galactosidase enzyme fragments (EA and PK). The resulting functional enzyme hydrolyzes substrate to generate a chemiluminescent signal. These cells have been modified to prevent long term propagation and expansion using a proprietary compound that has no apparent effect on assay performance.
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Size : 100 dp(1 x 96-well)/200 dp(2 x 96-well)/1000 dp(10 x 96-well)
Storage : Short term (2 weeks): Store in vapor phase of liquid N2

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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Which hormone does AVPR1B protein bind to? 11/03/2022

The AVPR1B protein binds to arginine vasopressin and, through its binding to arginine vasopressin, triggers the activation of intracellular signal transduction pathways.

What are the prospects of AVPR1B protein in drug development? 07/15/2022

AVPR1B has been implicated in a variety of neuropsychiatric disorders, and it is considered as a potential drug development target. Researchers are exploring the development of drugs that interact with AVPR1B protein for the treatment of related diseases.

What signal transduction pathways do AVPR1B proteins associate with? 03/14/2022

AVPR1B protein is associated with a variety of signal transduction pathways, including G protein-coupled receptor signal transduction, phosphatidylinositol signal transduction, protein kinase C signal transduction, etc.

In which tissues is AVPR1B protein expressed? 08/11/2021

The protein is mainly expressed in the central nervous system, including areas such as the anterior pituitary, hypothalamus, and hippocampus, and is also expressed at low levels in the adrenal gland and other tissues.

What are the structural features of the AVPR1B protein? 10/06/2020

The AVPR1B protein is a seven-fold transmembrane receptor protein with an N-terminal external domain and a C-terminal internal domain. The N-terminal external domain contains the site for binding to arginine vasopressin.

What is the role of AVPR1B protein in stress response? 01/20/2020

The protein is involved in the regulation of stress response by increasing the release of corticotrophin from the anterior pituitary in the central nervous system and regulating the levels of stress hormones, thereby affecting the generation and regulation of stress response.

Customer Reviews (3)

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10/27/2022

    The solubility is very good and can be easily dissolved in various buffers.

    07/06/2021

      Storage conditions are very simple and can be stored for a long time.

      01/08/2020

        Anti-pollution ability is very strong, not easy to be contaminated.

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