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AVPR2 CHO-K1 β-Arrestin GPCR Assay Kit

Cat.No. : Kit-1124
Product Overview : β-Arrestin GPCR cells are engineered to co-the ProLink (PK) tagged GPCR and the Enzyme Acceptor (EA) tagged β-Arrestin. Activation of the GPCR-PK induces β-Arrestin-EA recruitment, forcing complementation of the two β-galactosidase enzyme fragments (EA and PK). The resulting functional enzyme hydrolyzes substrate to generate a chemiluminescent signal. These cells have been modified to prevent long term propagation and expansion using a proprietary compound that has no apparent effect on assay performance.
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Size : 100 dp(1 x 96-well)/200 dp(2 x 96-well)/1000 dp(10 x 96-well)
Storage : Short term (2 weeks): Store in vapor phase of liquid N2

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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What is the role of AVPR2 protein in urine concentration? 04/27/2022

This protein promotes the production of cAMP in renal tubular epithelial cells by activating adenylyl cyclase-adenylyase system, thereby increasing the expression and transport of aquaporin-2 and increasing urine concentration.

What signal transduction pathways do AVPR2 proteins associate with? 09/07/2021

The protein is associated with signal transduction pathways related to adenylyl cyclase-adenylyl enzyme system and increases intracellular cAMP levels by activating adenylyl cyclase.

Which diseases are associated with AVPR2 protein mutations? 05/24/2021

Mutations in the AVPR2 protein are associated with nephrogenic diabetes insipidus, a disorder in which renal tubules are insensitive to arginine vasopressin, resulting in a failure to concentrate urine.

In which tissues is AVPR2 protein expressed? 08/22/2020

It is mainly expressed in renal tubules, especially at the apices of collecting duct cells.

What are the prospects of AVPR2 protein in drug development? 06/05/2020

Because of its involvement in the regulation of urine concentration and dilution, AVPR2 protein is considered a potential target for drug development. Researchers are exploring the development of drugs that interact with AVPR2 protein for the treatment of related diseases

Which hormone does AVPR2 protein bind to? 02/13/2019

AVPR2 protein binds to the antidiuretic hormone arginine vasopressin and, through its binding to arginine vasopressin, triggers the activation of intracellular signal transduction pathways.

Customer Reviews (3)

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09/05/2022

    Beacuse preparation cost is very low and the cost performance is very high.

    09/26/2019

      The activity retention time is very long and the activity can be maintained for a long time.

      03/23/2019

        This labeling effect is very good, and fluorescent labeling can be performed, etc.

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