AVPR2 CHO-K1 β-Arrestin GPCR Assay Kit
Cat.No. : | Kit-1124 |
Product Overview : | β-Arrestin GPCR cells are engineered to co-the ProLink (PK) tagged GPCR and the Enzyme Acceptor (EA) tagged β-Arrestin. Activation of the GPCR-PK induces β-Arrestin-EA recruitment, forcing complementation of the two β-galactosidase enzyme fragments (EA and PK). The resulting functional enzyme hydrolyzes substrate to generate a chemiluminescent signal. These cells have been modified to prevent long term propagation and expansion using a proprietary compound that has no apparent effect on assay performance. |
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Size : | 100 dp(1 x 96-well)/200 dp(2 x 96-well)/1000 dp(10 x 96-well) |
Storage : | Short term (2 weeks): Store in vapor phase of liquid N2 |
Products Types
◆ Recombinant Protein | ||
AVPR2-915M | Recombinant Mouse AVPR2 Protein, His (Fc)-Avi-tagged | +Inquiry |
AVPR2-2048P | Recombinant Pig AVPR2 Protein (292-370 aa), His-SUMO-tagged | +Inquiry |
AVPR2-564R | Recombinant Rat AVPR2 Protein, His (Fc)-Avi-tagged | +Inquiry |
AVPR2-3126C | Recombinant Chicken AVPR2 | +Inquiry |
AVPR2-1052HFL | Recombinant Human AVPR2 protein, His&Flag-tagged | +Inquiry |
◆ Lysates | ||
AVPR2-8557HCL | Recombinant Human AVPR2 293 Cell Lysate | +Inquiry |
◆ Assay kits | ||
Kit-1125 | cAMP AVPR2 CHO-K1 GPCR Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionThis protein promotes the production of cAMP in renal tubular epithelial cells by activating adenylyl cyclase-adenylyase system, thereby increasing the expression and transport of aquaporin-2 and increasing urine concentration.
The protein is associated with signal transduction pathways related to adenylyl cyclase-adenylyl enzyme system and increases intracellular cAMP levels by activating adenylyl cyclase.
Mutations in the AVPR2 protein are associated with nephrogenic diabetes insipidus, a disorder in which renal tubules are insensitive to arginine vasopressin, resulting in a failure to concentrate urine.
It is mainly expressed in renal tubules, especially at the apices of collecting duct cells.
Because of its involvement in the regulation of urine concentration and dilution, AVPR2 protein is considered a potential target for drug development. Researchers are exploring the development of drugs that interact with AVPR2 protein for the treatment of related diseases
AVPR2 protein binds to the antidiuretic hormone arginine vasopressin and, through its binding to arginine vasopressin, triggers the activation of intracellular signal transduction pathways.
Customer Reviews (3)
Write a reviewBeacuse preparation cost is very low and the cost performance is very high.
The activity retention time is very long and the activity can be maintained for a long time.
This labeling effect is very good, and fluorescent labeling can be performed, etc.
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