Nature Communication: Proteins that Make Difference between Cancerous and Healthy Cells Found

A recent study published in Nature Communication reveals how cancerous cells differ from healthy ones, which paves way for the development of novel strategies for the therapeutic intervention for difficult-to-treat cancers in the future.   An international research team discovered a “stop sign”- a mutated protein called PIP-stop, which is overused by tumor cells and can effectively prevent healthy cells from classifying in the way they are designed to.  …

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Recent Research Progress in Heart Disease (II)

heartbeat-heart-attack

(Continued)   4. Nat Commun: Latest research finds the key protein mechanism, which regulates heart and muscle   David Giganti et al, Disulfide isomerization reactions in titin immunoglobulin domains enable a mode of protein elasticity, Nature Communications (2018). DOI: 10.1038/s41467-017-02528-7     Scientists from CNIC and Columbia University have identified a key protein regulatory mechanism that regulates skeletal muscle and heart muscle function. Research results have recently been published in…

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Recent Research Progress in Heart Disease (I)

What we are bringing to you this time is recent advances in heart disease research and we hope it will be useful to you.   1. NEJM: Influenza increases the probability of heart attack by 6 times!   Jeffrey C. Kwong et al.Acute myocardial infarction after laboratory-confirmed influenza.N Engl J Med 2018; 378:345-353 DOI: 10.1056/NEJMoa1702090 infection     According to a recent study completed by ICRS and PHO researchers, the…

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Cell: TBK1 Is the Blockage to Weight Loss

Highlights TBK1 operates at the intersection of energy expenditure and inflammation TBK1 deficiency attenuates HFD-induced obesity but exaggerates inflammation TBK1 represses energy expenditure by phosphorylating and inhibiting AMPK TBK1 attenuates NF-κB activation and mediates the anti-inflammatory effect of AMPK   Do you ever wonder why fat body burns even fewer calories, or why dieting for weight loss always has bottlenecks? That’s because in both cases, our body tries to defend…

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Science: How Does the “Clock” Protein Work?

As we all know that the human body can function adaptively as the day and night change. And according to a new research from the Perelman School of Medicine at the University of Pennsylvania, a key protein called Rev-erb coordinates the ebb and flow of gene expression by tightening and loosening loops in chromosomes.   For the past 15 years, Mitchell A. Lazar et al. have been dedicated to revealing…

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Breakthrough! Scientists Decipher The Fifteen Years’ Unresolved Secrets of IL-23, Revealed The Key Mechanism of Autoimmune Disease!

Protein_IL23A

Recently an international team led by Professor Savvas Savvides at the VIB-UGent Inflammatory Research Center revealed the key molecular mechanisms of autoimmune and inflammatory diseases including psoriasis, rheumatoid arthritis, and Crohn’s disease. By focusing on the immunomodulatory factor IL-23, they found that its proinflammatory activity is strongly dependent on its receptor IL-23R for its structural activation. The research was published in Immunity recently.   Psoriasis, rheumatoid arthritis, inflammatory bowel disease…

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Is That True, Women Are More Likely to Survive Than Men?

Current research shows that women live longer than men. And a recent study found baby girls are more likely to survive in famine, epidemics and other unfortunate circumstances, why this happened? The research found that advantage of women may have existed very early.   Researchers believe that despite the small differences in gender behavior in infancy, the fact that women also have the advantage in infancy suggests that biology, at…

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Browning of Subcutaneous White Adipose Tissue Provides Outstanding Opportunity for Treatment of Obesity

convert white fat to brown fat

In a recent study published in the Journal of Experimental Medicine, researchers from Caroline College and other institutions studied mice to elucidate the molecular mechanism of conversion of energy-storing white fat into energy-consuming brown one.   Obesity is a major health problem for the global population, affecting people of all ages and increasing the risk of many diseases in humans, including cardiovascular disease, type 2 diabetes and cancers; although obesity…

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Scary! Pressure Will Accelerate The Occurrence of Malignant Pancreatic Cancer!

Pancreas

In a recent study published in the journal Cancer Cell, researchers from Columbia University Medical Center found that stress may accelerate the development of pancreatic cancer by stimulating the release of “fighting or running away” hormones, β-blockers that inhibit these hormones can effectively increase the survival of cancer-bearing mouse models. In addition, researchers analyzing patients with malignant pancreatic cancer found that patients taking selective β-blockers survived two-thirds more than the…

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New Drug Resistance Mechanism Found Through Persevere Research of Prostate Cancer

prostate cancer

Most tumor growing can stop after long-time medicine intake, and even it can become smaller or finally disappear. But what made the doctors struggling was that a few months later cancer cells gradually developed resistance and the tumor was once again deteriorating and menacing. Without good second-line anti-cancer drugs, physicians and patients really can do nothing. However, with the persevering efforts of scientists, we have the opportunity to gain the…

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