The occurrence of many childhood cancers often begins with molecular hijacking. Recently, a research report titled “Heterotypic interactions can drive selective co-condensation of prion-like low-complexity domains of FET proteins and mammalian SWI/SNF complex” was published in the journal Nature Communications. Scientists from institutions such as the University of Buffalo revealed through their research how fusion proteins intercept gene regulators to stimulate the development of cancer in children. In the…
The Influence of Age and Number of Mutations on the Size of Clonal Hematopoiesis
Hainan Medical College’s Ren Ruibao, Cai Wangwei, and Shanghai Jiao Tong University’s Chen Zhu jointly published a research paper on PNAS titled “The impact of age and number of mutations on the size of clonal hematopoiesis”, which reported an in-depth analysis of Clonal Hematopoiesis (CH) in the elderly population with longevity (age ≥ 90 years old) and general health (age 60-89 years old). This study utilized targeted deep sequencing and…
Research Progress on Structural Characteristics and Enzyme Activity Regulation Mechanisms of Viral Topoisomerases
Recently, Deng Zengqin’s team from the Chinese Academy of Sciences Wuhan Virus Research Institute/Antiviral Research Center completed the latest research achievement entitled “Structure-function analysis of the ATPase domain of African swine fever virus topoisomerase”, which was published online on mBio. DNA topoisomerases are widely present in archaea, prokaryotes, eukaryotes, and some nuclear-cytoplasmic large DNA viruses, playing important roles in gene replication, transcription, recombination, and chromosome separation processes. DNA topoisomerase…
Genetic Anxiety Switch in the Body
Recently, a research report titled “An ancient polymorphic regulatory region within the BDNF gene associated with obesity modulates anxiety-like behavior in mice and humans” was published in the journal Molecular Psychology. Scientists from institutions such as the University of Aberdeen found through their research that special DNA regions in the human genome may play an important role in controlling anxiety disorders in the body, this key gene may affect the…
How HIV Capsid Enters the Nuclear Pore Barrier Pathway
In a new study, Dr. David Jacques, a medical researcher at the University of New South Wales in Australia, and his team discovered how the human immunodeficiency virus (HIV) breaks through the nucleus to establish infection, a discovery that goes beyond the scope of HIV biology. The relevant research results were published online in the journal Nature, with the title “The HIV capsid mimics karyopherin engagement of FG-nucleoporins”. To…
The Mechanism by Which Leukemia Stem Cells Promote Their Own Growth after Chemotherapy
The mystery of why myeloid leukemia begins to grow again after chemotherapy kills most malignant cells and how to prevent growth through reused drugs may be solved through new research. The bone marrow of patients with acute myeloid leukemia (AML) contains a rare group of leukemia stem cells (LSCs) that do not grow and therefore are not killed by chemotherapy. However, after treatment, these cells began to grow and…
Potential Therapeutic Targets for Human Inflammatory Bowel Disease and Colitis Induced Colorectal Cancer
Intestinal inflammation can trigger a vicious cycle that disrupts the sensitive relationships between food, digestive acids, microorganisms, and the immune system, further promoting inflammation and sometimes even leading to tumor growth; Recently, a research report published in the journal JCI Insight titled “Farnesoid X receptor mediates macrophage-intrinsic responses to suppress colitis-induced colon cancer progression,” scientists from institutions such as the University of Wisconsin Madison identified a promising new target for…
TRIB3-TRIM8 Complex Regulates HNF4Α Stability to Promote the Progression of Non-Alcoholic Fatty Liver Disease
Hepatocellular endoplasmic reticulum stress plays an important role in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Hepatonuclear factor 4 α (HNF4α) reduced expression is an important event in the pathogenesis of non-alcoholic fatty liver and other liver diseases. Does endoplasmic reticulum stress regulate the expression of HNF4α is not clear yet. The purpose of this study is to elucidate the mechanism of HNF4 α protein degradation and exploration of…
Acinar-Ductal Cell Rearrangement Drives Branching Morphogenesis of the Murine Pancreas in an IGF/PI3K Dependent Manner
Many epithelial organs undergo branching morphogenesis during development, resulting in the construction of complex dendritic networks and the acquisition of specialized tissue structures. Understanding the establishment and maintenance of organizational structure is a core issue in developmental biology, which directly impacts organ physiology and diseases. In adult life, the loss of organizational structure may occur in the early stages and various human cancers. However how these processes are coordinated and…
PLA2G7-A New Breakthrough in Reversing the Immunosuppressive Microenvironment of Liver Cancer
Recently, a team led by Dong Ling from Zhongshan Hospital affiliated with Fudan University and Zhang Si from the School of Basic Medicine at Fudan University jointly published a new study in the Journal for ImmunoTherapy of Cancer, revealing the presence of a class of highly expressed platelet-activating factor acetylhydrolase (PLA2G7) and highly immunosuppressive TAMs in the microenvironment of hepatocellular carcinoma (HCC). Inhibiting PLA2G7 can improve the immune microenvironment and…