Cerebellar ataxia can occur as a result of many diseases and presents with symptoms of an inability to coordinate balance, gait, extremity and eye movements. There are many causes of cerebellar ataxia including, among others, autoimmunity to Purkinje cells or other neural cells in the cerebellum, CNS vacuities, multiple sclerosis, infection, bleeding, infarction, tumors, direct injury, toxins, genetic disorders, and an association with statin use. Inherited (genetic) forms of ataxia…
How About The Biological Science Funding Going Under Trump?
After the long campaign for the White House, Donald Trump became the new president of US. With just two months before his inauguration on 20 January, he and his staff are busy vetting candidates for top government jobs and clarifying the agenda for his first few months in office. We are waiting to see how Trump realizes his statements during the campaign. The most concerning thing for us is the…
Therapy in Inflammatory Bowel Diseases
Inflammatory bowel disease (IBD) is characterized by chronic intestinal inflammation and dysfunction of the epithelial barrier. The primary cause of the initiation of this disease is unclear. However, it is well accepted that inflammatory responses, most likely driven by the microbiome and defective barrier function, promote a vicious cycle that leads to chronic disease. The immune system and the microbiota mutually interact to maintain homeostasis in the intestine. However, components…
CXCL12-CXCR4/CXCR7, Two Axes to Repress Breast Cancer
Recently, there are two articles which reported the study on CXCL12 and breast cancer. Let’s take a glance on these new results. Breast cancer (BC) remains the most frequent cancer and the major cause of cancer-associated death in women. Based on histopathological analysis commonly used in clinical practice, BC has been identified as a heterogeneous disease classified into three main subtypes: Luminal (Lum), HER2 and triple-negative (TN), which have been…
Akt Protein Suppressed by pVHL Protein through Proline-hydroxylation–dependent Manner
Jianping Guo et al. studied the relationship between VHL protein and Akt protein, and their published their research results on Science Magazine (Science 26 Aug 2016: Vol. 353, Issue 6302, pp. 929-932 DOI: 10.1126/science.aad5755). Here we share this wonderful article hoping to help your research applications. Don’t forget that Creative Biomart provides VHL protein and Akt protein related molecular tools for you as always. [table caption=”Related Products” width=”800″ colwidth=”80|280|180″ colalign=”left|left|center|center|center”] Cat….
Genome-wide Association Studies for Cardiometabolic Risk Discovery: CMDs Downstream Gene-regulatory Mechanisms Exploring
Cardiovascular disease (CMDs) accounted for 17.5 million deaths in 2012. Coronary artery disease (CAD) and stroke are the primary diseases. Franzén et al. use Genome-wide Association Studies (GWAS) to identified downstream gene-regulatory mechanisms associated with risk for CMDs. They share their findings in Science Magazine (Science 19 Aug 2016: Vol. 353, Issue 6301, pp. 827-830 DOI: 10.1126/science.aad6970). Creative Biomart can provide you kinds of molecular tools such as recombinant Cardiovascular Proteins…
Histone Deacetylase Control endochondral bone formation by Cytokine Signaling and Matrix remodeling
Histone Deacetylase regulated the chondrocyte transcriptome by modifying the chromatin landscape and controlling non-histone protein activity. Carpio et al. found that HDAC3 promotes bone growth by restricting the secretion of inflammatory factors from chondrocytes and they publish their article on Science Signalling (Sci. Signal. 09 Aug 2016: Vol. 9, Issue 440, pp. ra79 DOI: 10.1126/scisignal.aaf3273). Here we share part of this wonderful article, and Creative Biomart Provides kinds of recombinant proteins for the research…
New Target For Neurodegenerative Diseases: RIPK1 Promoting Inflammation and Necroptosis in ALS
Ito et al. found that when RIPK1-kinase dependent signaling is disrupted in mice that lack optineurin, necroptosis is inhibited and axonal pathology is reversed. They share their findings on Science Magazine (Science 05 Aug 2016: Vol. 353, Issue 6299, pp. 603-608 DOI: 10.1126/science.aaf6803). We share this articles here for that Creative BioMart can provides kinds of recombinant and native Receptor-interacting kinase 1 (RIPK1) and Optn. [table caption=”Related Products” width=”800″ colwidth=”120|280|150″ colalign=”left|left|center|center|center”] Cat. #,Product name,Source(Host),Species,Conjugate RIPK1-14243M,Recombinant…
DNA Memories: In Vivo DNA Edit over Generations of Living Cells
Here we share an article which summary a DNA edit method in living cells (Science 29 Jul 2016: Vol. 353, Issue 6298, pp. 444-445 DOI: 10.1126/science.aah4438). Creative Biomart provides kinds of molecular tools for the synthetic biology research applications using DNA. Synthetic biology uses DNA programs to add new functions into living cells. By expressing transcription factors, microbes such as Escherichia coli can be made to perform complex computational logic and pass “memories” of selected…
Cyclin in Tumor: Cdk5 Disruption Promotes Antitumor Immunity
R. Dixon Dorand et al. have found that Cdk5 disruption can help outcome tumor medulloblastoma. They published their research results in Science Magazine (Science 22 Jul 2016: Vol. 353, Issue 6297, pp. 399-403 DOI: 10.1126/science.aae0477), and we share this wonderful article here. By the way, Creative Biomart provides kinds of molecular tools to promote your research about tumor therapy. [table caption=”Related Products” width=”800″ colwidth=”80|180|180″ colalign=”left|left|center|center|center”] Cat. #,Product name,Source(Host),Species,Conjugate CDK5-3204M,Recombinant Mouse CDK5 Protein,Mammalian…